Malignant complications of celiac disease: a case series and review of the literature

Journal of Medical Case Reports

Case Report

Jitka Prokesova¹  Barbora Packova¹  Milan Dastych¹  Radek Kroupa¹  Pavel Kohout²  Tomas Grolich³ 

[1] Department of Internal Medicine and Gastroenterology, University Hospital Brno, Faculty of Medicine, Masaryk University, Jihlavska 20, 62500, Brno, Czech Republic;Department of Internal Medicine, Third Faculty of Medicine, Charles University Prague and Teaching Thomayer Hospital, 14059, Prague, Czech Republic;Department of Surgery, University Hospital Brno, Faculty of Medicine, Masaryk University, 62500, Brno, Czech Republic;

关键词: Celiac disease;    Malignancy;    Complication;    Lymphoma;    Carcinoma;    Case report;   

DOI  :  10.1186/s13256-022-03682-3

 received in 2022-09-21, accepted in 2022-11-18,  发布年份 2022

来源: Springer

【 摘 要 】

BackgroundCeliac disease is an immune-mediated enteropathy triggered by gluten in genetically susceptible individuals. Diagnosis is based on evaluating specific autoantibodies and histopathologic findings of duodenal biopsy specimens. The only therapy for celiac disease is a gluten-free diet. Celiac disease can be complicated by malnutrition, other autoimmune diseases, refractoriness to treatment, and gastrointestinal tumors. This article presents seven cases of malignancies in patients with celiac disease. Its objective is to raise awareness of the malignant complications of celiac disease, leading to earlier diagnosis and improved outcomes.Case presentationSeven cases of malignant complications of celiac disease occurred among 190 patients followed at the Department of Internal Medicine and Gastroenterology, University Hospital Brno from 2014 to 2021. We describe these cases and the presentation, diagnostic process, course, management, and outcomes for each, along with proposed potential risk factors of malignant complications. There was one Caucasian man who was 70 years old and six Caucasian women who were 36, 46, 48, 55, 73, and 82 years old in our cohort. Of the seven cases of malignancies in our cohort, four patients were diagnosed with small bowel adenocarcinoma, one with diffuse large B-cell lymphoma, one with carcinoma of the tongue, and one with colorectal carcinoma.ConclusionsMalignancies occurred in 3.7% of patients followed up for celiac disease. Awareness of the malignant complications of celiac disease, risk factors, presentation, and disease course could lead to earlier diagnosis and improved outcomes.

【 授权许可】

CC BY   
© The Author(s) 2022

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