Optimization of the clinically approved Mg-Zn alloy system through the addition of Ca

Biomaterials Research

Research Article

Kang-Sik Lee¹  Minseong Chae¹  Dong-Ho Lee²  Hyung-Seop Han³  Gwang-Chul Lee³  Sun-Hee Lee³  Yu-Chan Kim³  Jaeho Park⁴  Hojeong Jeon⁵  Jeong-Yun Sun⁶  Do-Hyang Kim⁷  Hyung-Jin Roh⁸ 

[1] Biomedical Engineering Research Center, Asan Institute for Life Sciences, Asan Medical Center, College of Medicine, University of Ulsan, 05505, Seoul, Republic of Korea;Biomedical Engineering Research Center, Asan Institute for Life Sciences, Asan Medical Center, College of Medicine, University of Ulsan, 05505, Seoul, Republic of Korea;Department of Orthopedic Surgery, Asan Medical Center, College of Medicine, University of Ulsan, 05505, Seoul, Republic of Korea;Center for Biomaterials, Korea Institute of Science and Technology, 02792, Seoul, Republic of Korea;Center for Biomaterials, Korea Institute of Science and Technology, 02792, Seoul, Republic of Korea;Department of Materials science and Engineering, Seoul National University, 08826, Seoul, Republic of Korea;Center for Biomaterials, Korea Institute of Science and Technology, 02792, Seoul, Republic of Korea;KU-KIST Graduate School of Converging Science and Technology, Korea University, 02841, Seoul, Republic of Korea;Department of Materials science and Engineering, Seoul National University, 08826, Seoul, Republic of Korea;Nanostructural Material Laboratory, Department of Advanced Materials, Yonsei University, 03722, Seoul, Republic of Korea;Nanostructural Material Laboratory, Department of Advanced Materials, Yonsei University, 03722, Seoul, Republic of Korea;Center for Biomaterials, Korea Institute of Science and Technology, 02792, Seoul, Republic of Korea;Research and Development Center, U&I Corporation, 480-050, Uijongbu, Republic of Korea;

关键词: Biodegradable metal;    Micro-galvanic corrosion;    Mechanical properties;    Corrosion resistance;    In vitro;    Orthopedic implant;    Mg alloy;   

DOI  :  10.1186/s40824-022-00283-5

 received in 2022-04-24, accepted in 2022-07-04,  发布年份 2022

来源: Springer

【 摘 要 】

BackgroundAlthough several studies on the Mg-Zn-Ca system have focused on alloy compositions that are restricted to solid solutions, the influence of the solid solution component of Ca on Mg-Zn alloys is unknown. Therefore, to broaden its utility in orthopedic applications, studies on the influence of the addition of Ca on the microstructural, mechanical, and corrosion properties of Mg-Zn alloys should be conducted. In this study, an in-depth investigation of the effect of Ca on the mechanical and bio-corrosion characteristics of the Mg-Zn alloy was performed for the optimization of a clinically approved Mg alloy system comprising Ca and Zn.MethodsThe Mg alloy was fabricated by gravitational melting of high purity Mg, Ca, and Zn metal grains under an Ar gas environment. The surface and cross-section were observed using scanning electron microscopy (SEM) and transmission electron microscopy (TEM) to analyze their crystallographic structures. Electrochemical and immersion tests in Hank’s balanced salt solution were used to analyze their corrosion resistance. Tensile testing was performed with universal testing equipment to investigate the impact of Ca addition. The examination of cytotoxicity for biometric determination was in line with the ISO10993 standard.ResultsIn this study, the 0.1% Ca alloy had significantly retarded grain growth due to the formation of the tiny and well-dispersed Ca2Mg6Zn3 phase. In addition, the yield strength and elongation of the 0.1% Ca alloy were more than 50% greater than the 2% Zn alloy. The limited cell viability of the 0.3% Ca alloy could be attributed to its high corrosion rate, whereas the 0.1% Ca alloy demonstrated cell viability of greater than 80% during the entire experimental period.ConclusionThe effect of the addition of Ca on the microstructure, mechanical, and corrosion characteristics of Mg-Zn alloys was analyzed in this work. The findings imply that the Mg-Zn alloy system could be optimized by adding a small amount of Ca, improving mechanical properties while maintaining corrosion rate, thus opening the door to a wide range of applications in orthopedic surgery.

【 授权许可】

CC BY   
© The Author(s) 2022

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