Elevated serum Meteorin-like levels in patients with hyperthyroidism

BMC Endocrine Disorders

Research

Jiaxuan Wang¹  Qiu Wang¹  Xiaoyu Ding¹  Jia Liu¹  Guang Wang¹  Xiaona Chang¹  Xiaohui Wen² 

[1] Department of Endocrinology, Beijing Chao-Yang Hospital, Capital Medical University, NO. 8, Gongti South Road, 100020, Chaoyang District, Beijing, China;Department of Otolaryngology Head & Neck Surgery, Beijing Chao-Yang Hospital, Capital Medical University, 100020, Beijing, China;

关键词: Metrnl;    Hyperthyroidism;    Thyroid hormones;    Metabolism;   

DOI  :  10.1186/s12902-022-01229-7

 received in 2022-09-30, accepted in 2022-11-25,  发布年份 2022

来源: Springer

【 摘 要 】

BackgroundMeteorin-like (Metrnl) is a newly discovered adipomyokine that regulates systemic energy homeostasis. Both thyroid hormones and Metrnl increase energy expenditure and induce browning of adipose tissue. Thus, the aim of this study was to investigate serum Metrnl levels in hyperthyroid patients and the association of serum Metrnl levels with hyperthyroidism.MethodsThe study included 88 patients with newly diagnosed untreated overt hyperthyroidism and 100 age- and sex- matched healthy controls. Serum Metrnl levels were determined using the enzyme-linked immunosorbent assay (ELISA) method.ResultsSerum Metrnl levels were significantly elevated in patients with hyperthyroidism compared with controls. Linear regression analyses indicated that serum Metrnl levels were independently associated with FT3 (β = 0.324, P = 0.001), FT4 (β = 0.293, P = 0.001), and TSH (β = -0.234, P = 0.006) after full adjustment. Additionally, further logistic regression analyses revealed that the highest Metrnl tertile was significantly associated with hyperthyroidism compared with the lowest tertile (P for trend < 0.001). The relationship remained significant even after adjusting for potential confounders. Meanwhile, each one-unit increase in circulating Metrnl was independently associated with hyperthyroidism (OR 1.021, 95%CI 1.007–1.036, P < 0.01).ConclusionSerum Metrnl levels were elevated in patients with hyperthyroidism and were independently associated with hyperthyroidism.

【 授权许可】

CC BY   
© The Author(s) 2022

【 图 表 】

Fig. 2

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