An electrochemical nitric oxide generator for in-home inhalation therapy in pulmonary artery hypertension

BMC Medicine

Research Article

Zhuoming Xu¹  Bei Feng¹  Yi Yan²  Yiwei Liu³  Chenyu Jiang³  Yifan Zhu³  Hao Zhang⁴  Wen Mao⁵  Yuyan Zhang⁵  Zhanhao Su⁶  Xiaojian Wang⁶ 

[1] Heart Center and Shanghai Institute of Pediatric Congenital Heart Disease, Shanghai Children’s Medical Center, School of Medicine, Shanghai Jiao Tong University, 200127, Shanghai, China;Heart Center and Shanghai Institute of Pediatric Congenital Heart Disease, Shanghai Children’s Medical Center, School of Medicine, Shanghai Jiao Tong University, 200127, Shanghai, China;Institute for Cardiovascular Prevention (IPEK), Ludwig Maximilian University Munich, 80539, Munich, Germany;DZHK (German Centre for Cardiovascular Research), Partner site Munich Heart Alliance, 80539, Munich, Germany;Heart Center and Shanghai Institute of Pediatric Congenital Heart Disease, Shanghai Children’s Medical Center, School of Medicine, Shanghai Jiao Tong University, 200127, Shanghai, China;Shanghai Clinical Research Center for Rare Pediatric Diseases, Shanghai Children’s Medical Center, School of Medicine, Shanghai Jiao Tong University, 200127, Shanghai, China;Heart Center and Shanghai Institute of Pediatric Congenital Heart Disease, Shanghai Children’s Medical Center, School of Medicine, Shanghai Jiao Tong University, 200127, Shanghai, China;Shanghai Clinical Research Center for Rare Pediatric Diseases, Shanghai Children’s Medical Center, School of Medicine, Shanghai Jiao Tong University, 200127, Shanghai, China;State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, 100037, Beijing, China;Nanjing Novlead Biotechnology Corporation Limited, 211800, Nanjing, China;State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, 100037, Beijing, China;

关键词: Nitric oxide generator;    Inhalation therapy;    Pulmonary artery hypertension;   

DOI  :  10.1186/s12916-022-02686-6

 received in 2022-09-24, accepted in 2022-11-29,  发布年份 2022

来源: Springer

【 摘 要 】

BackgroundInhaled NO is a selective pulmonary vasodilator proven to be therapeutic for patients with pulmonary artery hypertension (PAH). The most common NO delivery system in clinical practice is cylinder-based, but unfortunately limited by its high costs, complicated delivery, and the requirement of an extensive supply chain, leaving vast unmet medical needs globally.MethodsTo address the need for rapid, affordable, and safe production of nitric oxide (NO) for in-home inhalation therapy in patients with PAH. We developed a novel portable device to derive NO from a nitrite complex solution with a copper(II)-ligand catalyst, and further examined its effectiveness in a porcine model of PAH. This model was established by using female Bama miniature pig and induced by monocrotaline (MCT) administration.ResultsThis generator could rapidly and safely produce therapeutic NO at concentrations ranging from 0 to 100 parts per million (ppm) with the least disproportionated nitrogen dioxide (NO2) and byproducts. It could effectively alleviate pulmonary arterial pressure (PAP) and pulmonary vascular resistance (PVR) in piglets with PAH, without causing major physiologic disruptions.ConclusionsOur electrochemical NO generator is able to produce the desired NO doses for pulmonary vasodilation in a safe and sustainable way, with low costs, which paves the way for its subsequent clinical trials in the patient with PAH and other common cardiopulmonary conditions with a high disease burden around the world.

【 授权许可】

CC BY   
© The Author(s) 2022

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