Absent in melanoma 2 (AIM2) in rheumatoid arthritis: novel molecular insights and implications

Cellular & Molecular Biology Letters

Review Letter

Steven J. Schrodi¹  Shicheng Guo¹  Dongyi He²  Jianan Zhao³ 

[1] Computation and Informatics in Biology and Medicine, University of Wisconsin-Madison, Madison, WI, USA;Department of Medical Genetics, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA;Department of Rheumatology, Shanghai Guanghua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China;Guanghua Clinical Medical College, Shanghai University of Traditional Chinese Medicine, Shanghai, China;Arthritis Institute of Integrated Traditional and Western Medicine, Shanghai Chinese Medicine Research Institute, Shanghai, China;Institute of Arthritis Research in Integrative Medicine, Shanghai Academy of Traditional Chinese Medicine, Shanghai, China;Department of Rheumatology, Shanghai Guanghua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China;Guanghua Clinical Medical College, Shanghai University of Traditional Chinese Medicine, Shanghai, China;Institute of Arthritis Research in Integrative Medicine, Shanghai Academy of Traditional Chinese Medicine, Shanghai, China;

关键词: Rheumatoid arthritis;    Autoimmune disease;    Absent in melanoma 2;    Inflammation;    Pyroptosis;    PANoptosis;   

DOI  :  10.1186/s11658-022-00402-z

 received in 2022-09-06, accepted in 2022-11-03,  发布年份 2022

来源: Springer

【 摘 要 】

Absent in melanoma 2 (AIM2), a member of the Pyrin and HIN domain protein family, is a cytoplasmic receptor that recognizes double-stranded DNA. AIM2 exhibits limited expression under physiological conditions but is widely expressed in many human diseases, including autoimmune diseases, and plays an essential role in the immune response. Rheumatoid arthritis (RA) is an autoimmune disease that poses a severe threat to physical and mental health, and is caused by several genetic and metabolic factors. Multiple immune cells interact to form a complex inflammatory network that mediates inflammatory responses and bone destruction. Abnormal AIM2 expression in multiple immune cell populations (T cells, B cells, fibroblast-like synoviocytes, monocytes, and macrophages) may regulate multiple functional responses in RA through mechanisms such as pyroptosis, PANoptosis, and regulation of other molecules. In this review, we describe and summarize the functional regulation and impact of AIM2 expression in immune cells to improve our understanding of the complex pathological mechanisms. These insights may provide potential directions for the development of new clinical diagnostic strategies for RA.

【 授权许可】

CC BY   
© The Author(s) 2022

【 图 表 】

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