Case report of Salmonella derby septicemia complicated with co-occurrence of disseminated intravascular coagulation and thrombotic microangiopathy

BMC Infectious Diseases

Case Report

Yingqun Chen¹  Sheng Zhang¹  Bin Huang¹  Yingxin Lin¹  Lei Huang¹  Weijia Li¹  Yunliang Tu¹ 

[1]Department of Intensive Care, Peking University Shenzhen Hospital, Shenzhen, China

关键词: Case report;    Co-occurrence;    Thrombotic microangiopathy;    Disseminated intravascular coagulation;    Thrombocytopenia;   

DOI  :  10.1186/s12879-022-07913-2

 received in 2022-07-13, accepted in 2022-12-01,  发布年份 2022

来源: Springer

【 摘 要 】

BackgroundBoth disseminated intravascular coagulation and thrombotic microangiopathy are complications of sepsis as Salmonella septicemia, respectively. They are related and have similar clinical characteristics as thrombopenia and organ dysfunctions. They rarely co-occur in some specific cases, which requires a clear distinction.Case presentationA 22-year-old woman had just undergone intracranial surgery and suffered from Salmonella derby septicemia with multiorgan involvement in the hospital. Laboratory workup demonstrated coagulation disorder, hemolytic anemia, thrombocytopenia, and acute kidney injury, leading to the co-occurrence of disseminated intravascular coagulation and secondary thrombotic microangiopathy. She received antibiotics, plasma exchange therapy, dialysis, mechanical ventilation, fluids, and vasopressors and gained full recovery without complications.ConclusionDisseminated intravascular coagulation and secondary thrombotic microangiopathy can co-occur in Salmonella derby septicemia. They should be treated cautiously in diagnosis and differential diagnosis. Thrombotic microangiopathy should not be missed just because of the diagnosis of disseminated intravascular coagulation. Proper and timely identification of thrombotic microangiopathy with a diagnostic algorithm is essential for appropriate treatment and better outcomes.

【 授权许可】

CC BY   
© The Author(s) 2022

【 图 表 】

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