Emerging roles and mechanisms of miR-206 in human disorders: a comprehensive review

Cancer Cell International

Review

Soudeh Ghafouri-Fard¹  Seyedeh Zahra Hosseini Imani²  Sheyda Khalilian³ 

[1] Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran;Division of Genetics, Department of Cell and Molecular Biology and Microbiology, Faculty of Biological Sciences and Technologies, University of Isfahan, Esfahān, Iran;Student Research Committee, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran;Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran;USERN Office, Shahid Beheshti University of Medical Sciences, Tehran, Iran;

关键词: miR-206;    Cancer;    Biomarkers;    Noncoding RNA;    microRNAs;   

DOI  :  10.1186/s12935-022-02833-2

 received in 2022-08-18, accepted in 2022-12-11,  发布年份 2022

来源: Springer

【 摘 要 】

As a member of the miR-1 family, miR-206 is located between IL-17 and PKHD1 genes in human. This miRNA has been shown to be involved in the pathogenic processes in a variety of human disorders including cancers, amyotrophic lateral sclerosis, Alzheimer’s disease, atherosclerosis, bronchopulmonary dysplasia, coronary artery disease, chronic obstructive pulmonary disease, epilepsy, nonalcoholic fatty liver disease, Hirschsprung disease, muscular dystrophies, pulmonary arterial hypertension, sepsis and ulcerative colitis. In the current review, we summarize the role of miR-206 in both malignant and non-malignant situations and explain its possible therapeutic implications.

【 授权许可】

CC BY   
© The Author(s) 2022

【 图 表 】

Fig. 3

Fig. 1

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