Dopamine-triggered one-step functionalization of hollow silica nanospheres for simultaneous lubrication and drug release

Friction

Research Article

Qiangbing Wei¹  Yixin Zhang¹  Lele Lei¹  Huan Liu²  Tian Fu²  Feng Zhou³  Shuanhong Ma⁴ 

[1] Key Laboratory of Eco-functional Polymer Materials of the Ministry of Education, Key Laboratory of Polymer Materials of Gansu Province, College of Chemistry and Chemical Engineering, Northwest Normal University, 730070, Lanzhou, China;Key Laboratory of Eco-functional Polymer Materials of the Ministry of Education, Key Laboratory of Polymer Materials of Gansu Province, College of Chemistry and Chemical Engineering, Northwest Normal University, 730070, Lanzhou, China;State Key Laboratory of Solid Lubrication, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, 730000, Lanzhou, China;State Key Laboratory of Solid Lubrication, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, 730000, Lanzhou, China;State Key Laboratory of Solid Lubrication, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, 730000, Lanzhou, China;Shandong Laboratory of Yantai Advanced Materials and Green Manufacture, 264006, Yantai, China;

关键词: osteoarthritis treatment;    functionalized nanoparticles;    injectable biolubricant;    friction reduction;    drug release;   

DOI  :  10.1007/s40544-022-0605-x

 received in 2021-09-28, accepted in 2022-01-31,  发布年份 2022

来源: Springer

【 摘 要 】

Osteoarthritis (OA) has been regarded as a lubrication deficiency related joint disease. Combination of both joint lubrication and drug intervention may provide a promising nonsurgical strategy for treatment of OA. Developing novel and simple approaches to fabricate superlubricating nanoparticles with drug release property is highly required. Herein, dopamine triggered one-step polymerization method was employed to fabricate polydopamine/poly(3-sulfopropyl methacrylate potassium salt) (PDA—PSPMA) conjugate coating on hollow silica (h-SiO2) nanosphere surfaces to engineer functional nanoparticles (h-SiO2/PDA—PSPMA). The as-prepared h-SiO2/PDA—PSPMA exhibits excellent aqueous lubrication performance on biomaterial substrates as well as natural bovine articular cartilage based on hydration effect of negatively charged PDA—PSPMA coating and “rolling” effect of h-SiO2 nanospheres. In vitro drug loading-release experiments demonstrate that PDA—PSPMA coating functionalized h-SiO2 nanospheres show high drug-loading and sustained-release capability of an anti-inflammatory drug, diclofenac sodium (DS). Such h-SiO2/PDA—PSPMA nanospheres can be potentially used as a synergistic therapy agent for OA treatment combining by simultaneous joint lubrication and drug release.

【 授权许可】

CC BY   
© The author(s) 2022

【 图 表 】

Fig. 1