Strategies of cell and cell-free therapies for periodontal regeneration: the state of the art

Stem Cell Research & Therapy

Review

Jinlong Chen¹  Xiuting Wang¹  Weidong Tian¹ 

[1] State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, West China School of Stomatology, Sichuan University, Chengdu, People’s Republic of China;National Engineering Laboratory for Oral Regenerative Medicine, West China School of Stomatology, Sichuan University, Chengdu, People’s Republic of China;Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, 610041, Chengdu, People’s Republic of China;

关键词: Periodontal regeneration;    Tissue engineering;    Endogenous regeneration;    Biomimetic design;    Extracellular matrix;   

DOI  :  10.1186/s13287-022-03225-z

 received in 2022-08-14, accepted in 2022-12-19,  发布年份 2022

来源: Springer

【 摘 要 】

BackgroundPeriodontitis often causes irrevocable destruction of tooth-supporting tissues and eventually leads to tooth loss. Currently, stem cell-based tissue engineering has achieved a favorable result in regenerating periodontal tissues. Moreover, cell-free therapies that aim to facilitate the recruitment of resident repair cell populations to injured sites by promoting cell mobilization and homing have become alternative options to cell therapy.Main textCell aggregates (e.g., cell sheets) retain a large amount of extracellular matrix which can improve cell viability and survival rates after implantation in vivo. Electrostatic spinning and 3D bioprinting through fabricating specific alignments and interactions scaffold structures have made promising outcomes in the construction of a microenvironment conducive to periodontal regeneration. Cell-free therapies with adding biological agents (growth factors, exosomes and conditioned media) to promote endogenous regeneration have somewhat addressed the limitations of cell therapy.ConclusionHence, this article reviews the progress of stem cell-based tissue engineering and advanced strategies for endogenous regeneration based on stem cell derivatives in periodontal regeneration.

【 授权许可】

CC BY   
© The Author(s) 2022

【 图 表 】

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