An explorative epigenome-wide association study of plasma renin and aldosterone concentration in a Ghanaian population: the RODAM study

Clinical Epigenetics

Research

Peter Henneman¹  Andrea Venema¹  Charles Hayfron-Benjamin²  Charles Agyemang³  Adrienne Halley³  Felix Chilunga³  Karlijn A. C. Meeks⁴  Bert-Jan van den Born⁵  Eva L. van der Linden⁵  Ingrid M. Garrelds⁶  A. H. Jan Danser⁶ 

[1] Department of Human Genetics, Genome Diagnostics Laboratory Amsterdam, Amsterdam UMC, University of Amsterdam, Amsterdam Reproduction and Development, Amsterdam, The Netherlands;Department of Physiology, University of Ghana Medical School, Accra, Ghana;Department of Anesthesia and Critical Care, Korle Bu Teaching Hospital, Accra, Ghana;Department of Public and Occupational Health, Amsterdam UMC, University of Amsterdam, Amsterdam Public Health Research Institute, Location AMC, Meibergdreef 9, 1105AZ, Amsterdam, The Netherlands;Department of Public and Occupational Health, Amsterdam UMC, University of Amsterdam, Amsterdam Public Health Research Institute, Location AMC, Meibergdreef 9, 1105AZ, Amsterdam, The Netherlands;Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA;Department of Public and Occupational Health, Amsterdam UMC, University of Amsterdam, Amsterdam Public Health Research Institute, Location AMC, Meibergdreef 9, 1105AZ, Amsterdam, The Netherlands;Department of Vascular Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam Cardiovascular Sciences, Amsterdam, The Netherlands;Division of Pharmacology and Vascular Medicine, Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Amsterdam, The Netherlands;

关键词: DNA methylation;    Epigenome-wide association study;    Renin;    Aldosterone;    RAAS;    Hypertension;    Sub-Saharan Africa;    RODAM;   

DOI  :  10.1186/s13148-022-01378-5

 received in 2022-10-06, accepted in 2022-11-16,  发布年份 2022

来源: Springer

【 授权许可】

CC BY   
© The Author(s) 2022

【 图 表 】

Fig. 2