Protective effects of Lactobacillus reuteri SJ-47 strain exopolysaccharides on human skin fibroblasts damaged by UVA radiation

Bioresources and Bioprocessing

Research

Meng Li¹  Jingsha Zhao¹  Changtao Wang¹  Jiachan Zhang¹  Hao Fu¹  Yongtao Zhang¹  Dongdong Wang¹  Dan Zhao¹ 

[1] Beijing Key Laboratory of Plant Resource Research and Development, College of Chemistry and Materials Engineering, Beijing Technology and Business University, Beijing, People’s Republic of China;Institute of Cosmetic Regulatory Science, Beijing Technology and Business University, Beijing, People’s Republic of China;

关键词: Lactobacillus reuteri;    Skin photoaging;    Oxidative stress;   

DOI  :  10.1186/s40643-022-00617-0

 received in 2022-08-13, accepted in 2022-12-02,  发布年份 2022

来源: Springer

【 摘 要 】

Ultraviolet rays in sunlight can cause skin damage and premature aging. This study demonstrates that Lactobacillus reuteri SJ-47 strain exopolysaccharides (EPS) protect human skin fibroblasts (HSF) under UVA radiation. During the course of the experiments, we investigate the oxidative stress protection and antiaging effects of exopolysaccharides on HSF at the biochemical, cellular, and molecular levels. The results show that EPS can increase the antioxidant capacity of cells, decrease the amount of reactive-oxygen species (ROS) and malondialdehyde (MDA), while improve the expression of antioxidant enzymes. At the same time, EPS can increase collagen content, which can effectively regulate the expression of genes in the senescence and apoptosis pathways, and delay skin photoaging caused by UVA irradiation.Graphical Abstract

【 授权许可】

CC BY   
© The Author(s) 2022

【 图 表 】

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