The clinical manifestation and the influence of age and comorbidities on long-term chikungunya disease and health-related quality of life: a 60-month prospective cohort study in Curaçao

BMC Infectious Diseases

Research

Izzy Gerstenbluth¹  Ashley Duits¹  Johannes Burgerhof²  Ajay Bailey³  Adriana Tami⁴  Churnalisa Doran⁴  Yaskara Halabi⁵  Norediz Lourents⁵ 

[1] Curaçao Biomedical and Health Research Institute, Pater Eeuwensweg 36, Willemstad, Curaçao;Department of Epidemiology, University Medical Center Groningen, Hanzeplein 1, 9713 GZ, Groningen, The Netherlands;Department of Human Geography and Spatial Planning, University of Utrecht, Heidelberglaan 8, 3584 CS, Utrecht, The Netherlands;Department of Medical Microbiology and Infection Prevention, University Medical Center Groningen, Hanzeplein 1, 9713 GZ, Groningen, The Netherlands;Epidemiology and Research Unit, Medical and Public Health Service Curaçao, Piscaderaweg 49, Willemstad, Curaçao;

关键词: Chikungunya;    Asian;    Genotype;    Chronic;    Long-term;    Rheumatic;    Arthralgia;    Health-related quality of life;   

DOI  :  10.1186/s12879-022-07922-1

 received in 2022-03-28, accepted in 2022-12-06,  发布年份 2022

来源: Springer

【 摘 要 】

BackgroundPersistent rheumatic symptoms and its impact on health-related quality of life (QoL), induced by the Indian Ocean Lineage (IOL) chikungunya virus (CHIKV) genotype have been widely studied. In 2014, a major CHIKV outbreak of the Asian genotype occurred in Curaçao, after which we established a longitudinal cohort in 2015, to follow the long-term CHIKV sequalae. Currently, the long-term clinical manifestations and its impact on QoL induced by the Asian CHIKV genotype, followed prospectively through time, and the association of age and comorbidities with rheumatic symptoms persistence, 60 months (M60) after disease onset is unknown.MethodsThe cohort of 304 laboratory confirmed patients were followed prospectively in time at 3–16 months (M3-16), 30 months (M30), and M60 after disease onset. Demographic and clinical characteristics, and the 36-item short-form survey (SF-36) QoL status were collected through questionnaires. At M60, QoL scores were compared to general population (CHIK-) norms.ResultsA total of 169 (56%) patients participated (74.6% female, mean age 56.1 years) at all time points, 107 (63%) were classified as recovered and 62 (37%) as affected. The affected patients reported an increase in the prevalence of arthralgia (P .001) and arthralgia in the lower extremities (P < .001), at M30 compared to M3-16. At M60, in comparison to recovered patients, affected patients reported a higher prevalence of recurrent rheumatic symptoms of moderate to severe pain, irrespective of age and comorbidities, and a higher prevalence of non-rheumatic symptoms (P < .001). Arthralgia in the upper (odds ratio (OR): 4.79; confidence interval (CI): 2.01–11.44; P < .001) and lower (OR: 8.68; CI: 3.47–21.69; P < .001) extremities, and headache (OR: 3.85; CI: 1.40–10.54; P = .009) were associated with being affected. The SF-36 QoL scores of the recovered patients were less impaired over time compared to the QoL scores of the affected patients. At M60, the QoL scores of the recovered patients were comparable to the CHIK- QoL scores.ConclusionsRheumatic and non-rheumatic symptoms, and QoL impairment may persist, 60 months following infection with the Asian CHIKV genotype, similar to the IOL genotype disease sequelae. Further research is needed to follow the clinical manifestations and QoL impact of each CHIKV genotype.

【 授权许可】

CC BY   
© The Author(s) 2022

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