Association between physical activity and risk of renal function decline and mortality in community-dwelling older adults: a nationwide population-based cohort study

BMC Geriatrics

Research

Chi-Yeon Lim¹  Mun Jung Ko¹  Sang Heon Song²  Yu Ah Hong³  Sung Joon Shin⁴  Eunjin Bae⁵  Hyunsuk Kim⁶  Young Youl Hyun⁷  Woo Yeong Park⁸  Won Min Hwang⁹  Gang-Jee Ko^1,10  Jang-Hee Cho^1,11  In O Sun^1,12  Byung Chul Yu^1,13  Soon Hyo Kwon^1,14  Kyung Don Yoo^1,15  Sungjin Chung^1,16  Jae Won Yang^1,17 

[1] Department of Biostatistics, Dongguk University College of Medicine, Goyang-Si, Republic of Korea;Division of Nephrology, Department of Internal Medicine and Biomedical Research Institute, Pusan National University Hospital, Busan, Republic of Korea;Division of Nephrology, Department of Internal Medicine, Daejeon St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, #64, Daeheung-Ro, Jung-Gu, 34943, Daejeon, Republic of Korea;Division of Nephrology, Department of Internal Medicine, Dongguk University Ilsan Hospital, Dongguk University School of Medicine, Goyang, Republic of Korea;Division of Nephrology, Department of Internal Medicine, Gyeongsang National University College of Medicine, Jinju, Republic of Korea;Division of Nephrology, Department of Internal Medicine, Hallym University Medical Center, Chuncheon Sacred Heart Hospital, Chuncheon, Republic of Korea;Division of Nephrology, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University, School of Medicine, Seoul, Republic of Korea;Division of Nephrology, Department of Internal Medicine, Keimyung University Dongsan Hospital, Keimyung University School of Medicine, Daegu, Republic of Korea;Division of Nephrology, Department of Internal Medicine, Konyang University Hospital, Daejeon, Republic of Korea;Division of Nephrology, Department of Internal Medicine, Korea University Guro Hospital, Korea University College of Medicine, Seoul, Republic of Korea;Division of Nephrology, Department of Internal Medicine, Kyungpook National University Hospital, School of Medicine, Kyungpook National University, Daegu, Republic of Korea;Division of Nephrology, Department of Internal Medicine, Presbyterian Medical Center, Jeonju, Republic of Korea;Division of Nephrology, Department of Internal Medicine, Soonchunhyang University Bucheon Hospital, Bucheon, Republic of Korea;Division of Nephrology, Department of Internal Medicine, Soonchunhyang University Seoul Hospital, Seoul, Republic of Korea;Division of Nephrology, Department of Internal Medicine, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Republic of Korea;Division of Nephrology, Department of Internal Medicine, Yeouido St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea;Division of Nephrology, Department of Internal Medicine, Yonsei University Wonju College of Medicine, Wonju, Republic of Korea;

关键词: Physical activity;    Renal function;    Mortality;    Older adults;   

DOI  :  10.1186/s12877-022-03693-1

 received in 2022-08-01, accepted in 2022-12-09,  发布年份 2022

来源: Springer

【 摘 要 】

BackgroundPhysical activity (PA) is an important risk factor associated with health outcomes. However, the relationship between PA and kidney function decline in older adults remains unclear. We examined the influence of PA on kidney function decline and mortality in community-dwelling older adults.MethodsAdults aged ≥ 65 years with an estimated glomerular filtration rate (eGFR) > 60 mL/min/1.73 m2 who had available health checkup data from 2009 to 2010 were included. The cohort was followed annually through December 2015 for anthropometric, sociodemographic, and medical information including outcomes and biennially for laboratory information from the health checkup. We divided these patients into three groups according to self-reported PA (Inactive group: no leisure-time PA, Active group: vigorous activity for at least 80 min/week or a sum of moderate-intensity activity and walking for at least 300 min/week, Low-active group: level of PA between the definitions of the other two groups). Associations between the intensity of PA and death, cardiovascular death, and ≥ 50% eGFR decline were investigated.ResultsAmong 102,353 subjects, 32,984 (32.23%), 54,267 (53.02%), and 15,102 (14.75%) were classified into the inactive, low-active, and active groups, respectively. The active group was younger, contained a higher proportion of men, and had higher frequencies of hypertension, diabetes mellitus, drinking, and smoking than the other groups. The active group had significantly lower incidence rates of mortality, cardiovascular mortality, and kidney function decline than the other groups (all p < 0.001). The active group also showed lower all-cause (hazard ratio [HR], 0.76; 95% confidence interval [CI], 0.70–0.82) and cardiovascular mortality (HR, 0.64; 95% CI, 0.53–0.78) and protection against ≥ 50% eGFR decline (HR, 0.81; 95% CI, 0.68–0.97) compared with the inactive group in the fully adjusted Cox proportional hazards regression model.ConclusionsHigh PA was an independent modifiable lifestyle factor for reducing mortality and protecting against declines in kidney function in older adults.

【 授权许可】

CC BY   
© The Author(s) 2022

【 图 表 】

Fig. 4

12864_2022_9026_Article_IEq187.gif

12951_2022_1749_Article_IEq1.gif