All-cause mortality after major gastrointestinal bleeding among patients receiving direct oral anticoagulants: a protocol for a systematic review and meta-analysis

Systematic Reviews

Protocol

Roupen Odabashian¹  Jenneke Leentjens²  Fabian Stucki³  Tobias Tritschler⁴  Deborah M. Siegal⁵  Valentina Ly⁶  Faizan Khan⁷  Nicholas L. J. Chornenki⁸ 

[1] Clinical Epidemiology Program, The Ottawa Hospital Research Institute, Ottawa, ON, Canada;Clinical Epidemiology Program, The Ottawa Hospital Research Institute, Ottawa, ON, Canada;Radboud University Medical Center, Radboud University, Nijmegen, Netherlands;Department of General Internal Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland;Department of General Internal Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland;Department of Medicine, University of Ottawa, Ottawa, ON, Canada;Clinical Epidemiology Program, The Ottawa Hospital Research Institute, Ottawa, ON, Canada;Department of Medicine, University of Ottawa, Ottawa, ON, Canada;Clinical Epidemiology Program, The Ottawa Hospital Research Institute, Ottawa, ON, Canada;School of Epidemiology and Public Health, University of Ottawa, Ottawa, ON, Canada;Department of Medicine, University of Ottawa, Ottawa, ON, Canada;Health Sciences Library, University of Ottawa, Ottawa, Canada;Department of Medicine, University of Ottawa, Ottawa, ON, Canada;School of Epidemiology and Public Health, University of Ottawa, Ottawa, ON, Canada;Internal Medicine Residency Program, Queens University, Kingston, ON, Canada;

关键词: Bleeding;    Direct oral anticoagulants;    Mortality;    Anticoagulation;   

DOI  :  10.1186/s13643-022-02146-5

 received in 2022-04-14, accepted in 2022-11-28,  发布年份 2022

来源: Springer

【 摘 要 】

BackgroundGastrointestinal (GI) bleeding represents the single most frequent site of anticoagulant-related bleeding. Adverse outcomes after major GI bleeding including mortality are not well characterized and, as a result, may be underappreciated in clinical practice. We aim to conduct a systematic review and meta-analysis of the risk for 30-day all-cause mortality after major GI bleeding among patients receiving DOACs.MethodsElectronic databases including MEDLINE, EMBASE, and Cochrane CENTRAL will be systematically searched to identify randomized controlled trials and prospective and retrospective cohort studies reporting 30-day all-cause mortality in adults with DOAC-related major GI bleeding. At least two investigators will independently perform study selection, risk of bias assessment, and data extraction. The proportion of deaths following a major GI event relative to the number of major GI bleeding events will be calculated for each individual study, and results across studies will be pooled using random-effects meta-analysis. We will assess risk of bias using criteria proposed by the GRADE group for prognostic studies.DiscussionThe findings of this systematic review and meta-analysis will provide clinicians and patients with estimates of mortality after the most common major bleeding event to support shared decision making about anticoagulation management.Trial registrationPROSPERO CRD42022295815.

【 授权许可】

CC BY   
© The Author(s) 2022