Relationship between dry eye and expressions of CXCR3 and CCR5 after ocular acid burn

BMC Ophthalmology

Research

Qianqian Hu¹  Xiaodong Zhou²  Tao Li²  Man She²  Chunxia Li³  Bo Jiang⁴ 

[1] Department of Ophthalmology, Huadong Hospital Affiliated to Fudan University, Shanghai, China;Department of Ophthalmology, Jinshan Hospital Affiliated to Fudan University, Shanghai, China;Department of Ophthalmology, Shanghai TCM-Integrated Hospital, Shanghai University of TCM, Shanghai, China;Shanghai University of Traditional Chinese Medicine, Shanghai, China;Department of Ophthalmology, Jinshan Hospital Affiliated to Fudan University, Shanghai, China;

关键词: Burn;    Acid;    Ocular;    CXCR3;    CCR5;   

DOI  :  10.1186/s12886-022-02678-3

 received in 2021-11-27, accepted in 2022-11-08,  发布年份 2022

来源: Springer

【 摘 要 】

ObjectiveTo investigate the manifestation of dry eye and its relationship with CXCR3 and CCR5 expression in patients with ocular acid burns.MethodsThis is a case–control study. A total of 27 eyes of 22 cases ocular with acid burns of I-V degrees from Jan.2020 to Feb.2021 in Jinshan Hospital of Fudan University were selected as observation group, and 8 eyes of 8 cases of normal people were selected as control group. The follow-up period was 3 months. The visual acuity, intraocular pressure (IOP), corneal fluorescein staining scores (CFS), breakup time of tear film (BUT), Schirmer I test, corneal thickness and tear meniscus height (TMH) were observed at 1 day, 1 and 3 months after injury. The protein expressions of CXCR3 and CCR5 were examined by ELISA and compared among groups at each time point.ResultsBUT and Schirmer I tests value in the observation group were lower than those in the control group 3 months after injury (BUT: Group I ~ IV p = 0.0266, p = 0.0222, p = 0.0003, p = 0.0059, respectively; Schirmer I test: Group I ~ IV p = 0.0027, p = 0.0033, p = 0.0016, p = 0.0032, respectively). CFS scores were higher than those in the control group at 1 day after injury (all p < 0.0001), but decreased gradually at 1 and 3 months after injury (Group I ~ IV p = 0.0042, p = 0.0096, p < 0.0001, p < 0.0001, respectively). The corneal thickness and TMH 1 day after injury were higher than those in the control group (corneal thickness: Group II ~ IV p = 0.0010, p < 0.0001, p < 0.0001, respectively; TMH: Group II ~ IV p = 0.0002, p < 0.0001, p < 0.0001, respectively), and also higher than those at 1 month and 3 months after injury (corneal thickness: Group II ~ IV p = 0.0010, p < 0.0001, p < 0.0001, respectively; TMH: Group II ~ IV p = 0.0345 and p = 0.0045, p = 0.0005 and p < 0.0001, p = 0.0114 and p = 0.0019, respectively). The expression levels of CXCR3 and CCR5 protein were significantly negatively correlated with BUT (all p < 0.0001), and CXCR3 and CCR5 were also significantly negatively correlated with Schirmer I test value (p < 0.0001, p = 0.0004, respectively).ConclusionOcular acid burns can cause dry eye, and the expression of CXCR3 and CCR5 protein in tears may be related to the occurrence of dry eye after ocular acid burn.

【 授权许可】

CC BY   
© The Author(s) 2022

【 图 表 】

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