Research trends and hotspots of recurrent pregnancy loss with thrombophilia: a bibliometric analysis

BMC Pregnancy and Childbirth

Research

Jun Guo¹  Feng Zhao¹  Sheng-Jing Liu¹  Ming Zhao¹  Ying-jun Deng²  Yu-xiao Huang³ 

[1] Department of Andrology, Xiyuan Hospital of China Academy of Chinese Medical Sciences, 100091, Beijing, China;Department of Andrology, Xiyuan Hospital of China Academy of Chinese Medical Sciences, 100091, Beijing, China;Department of Obstetrics and Gynecology, Xiyuan Hospital of China Academy of Chinese Medical Sciences, No.1 Xiyuan Cao Chang, Zhongzhi Road, 100091, Beijing, China;Department of Obstetrics and Gynecology, Xiyuan Hospital of China Academy of Chinese Medical Sciences, No.1 Xiyuan Cao Chang, Zhongzhi Road, 100091, Beijing, China;

关键词: Thrombophilia;    Recurrent pregnancy loss;    Bibliometric analysis;   

DOI  :  10.1186/s12884-022-05210-z

 received in 2022-06-22, accepted in 2022-11-11,  发布年份 2022

来源: Springer

【 摘 要 】

BackgroundThrombophilia is a group of disorders that result in a blood hypercoagulable state and induce thrombosis, which was found widely existed in recurrent pregnancy loss (RPL). More and more research about thrombophilia has been conducted but the association between thrombophilia and RPL remains uncertain. Thus, it’s necessary to combine relevant literature to find the research hotspots and analyze the internal link between different study points, and then predict the development trend in RPL with thrombophilia.MethodsRelevant articles between 1970 and 2022 were obtained from the Web of Science (WoS) database. Software VOSviewer and CiteSpace were used to perform the analysis and conduct visualization of scientific productivity and emerging trends.ResultsSeven hundred twenty-five articles published in recent 30 years by 3205 authors from 1139 organizations and 68 countries were analyzed. 37authors, 38 countries, and 53 organizations published papers ≥5. The United States was the most productive country and Univ Amsterdam was the most productive institution. Journal thrombosis and haemostasis had the most total citations. In keyword and clusters, factor-v-Leiden, inherited thrombophilia, activated protein-c, low-dose aspirin, molecular-weigh heparin, polymorphism had high-frequency focus on its etiology, diagnostics, and therapeutics. The strongest keyword bursts showed the research hotspots changed over time.ConclusionsThere could be differences in the clinical relevance of different type of thrombophilia, as well as single and multiple thrombophilic factors. Anticoagulation and immunotherapy are currently the main treatment options. More clinical trials and basic research are expected and we should attach more attention to the whole management of in-vitro fertilization in the future.

【 授权许可】

CC BY   
© The Author(s) 2022

【 图 表 】

12864_2022_9026_Article_IEq102.gif

Fig. 8

Fig. 3

Fig. 1

Fig. 1

Fig. 1