Per- and polyfluoroalkyl substances (PFAS) exposure in melanoma patients: a retrospective study on prognosis and histological features

Environmental Health

Research

Franco Bassetto¹  Alessandra Buja²  Lorenzo Nicolè³  Clara Benna⁴  Alessandro Dal Monico⁵  Mauro Alaibac⁵  Chiara Menin⁶  Francesco Cavallin⁷  Vanna Chiarion-Sileni⁸  Jacopo Pigozzo⁸  Luisa Piccin⁸  Rocco Cappellesso⁹  Angelo Paolo Dei Tos^1,10  Beatrice Ferrazzi^1,11  Paolo Del Fiore^1,12  Giulia Tadiotto^1,12  Marcodomenico Mazza^1,12  Claudia Cozzolino^1,12  Antonella Vecchiato^1,12  Saveria Tropea^1,12  Simone Mocellin^1,13  Irene Russo^1,14 

[1] Clinic of Plastic Surgery, Department of Neuroscience, Padua University Hospital, University of Padova, Padua, Italy;Department of Cardiological, Thoracic, Vascular Sciences and Public Health, University of Padova, 35128, Padua, Italy;Department of Medicine (DIMED), Unit of Pathology & Cytopathology, University of Padova, 35128, Padua, Italy;Unit of Surgical Pathology & Cytopathology, Ospedale Dell’Angelo, 30174, Mestre, Italy;Department of Surgery, Oncology and Gastroenterology (DISCOG), University of Padova, 35128, Padua, Italy;Division of Dermatology, Department of Medicine (DIMED), University of Padova, 35128, Padua, Italy;Immunology and Diagnostic Molecular Oncology Unit, Veneto Institute of Oncology IOV-IRCCS, 35128, Padua, Italy;Independent Statistician, 36020, Padua, Solagna, Italy;Melanoma Unit, Oncology 2, Veneto Institute of Oncology IOV-IRCCS, 35128, Padua, Italy;Pathological Anatomy Unit, University Hospital of Padova, 35128, Padua, Italy;Pathological Anatomy Unit, University Hospital of Padova, 35128, Padua, Italy;Department of Medicine- DIMED, University of Padova, 35128, Padua, Italy;Postgraduate School of Occupational Medicine, University of Verona, 37129, Verona, Italy;Soft-Tissue, Peritoneum and Melanoma Surgical Oncology Unit, Veneto Institute of Oncology IOV-IRCCS, 35128, Padua, Italy;Soft-Tissue, Peritoneum and Melanoma Surgical Oncology Unit, Veneto Institute of Oncology IOV-IRCCS, 35128, Padua, Italy;Department of Surgery, Oncology and Gastroenterology (DISCOG), University of Padova, 35128, Padua, Italy;Soft-Tissue, Peritoneum and Melanoma Surgical Oncology Unit, Veneto Institute of Oncology IOV-IRCCS, 35128, Padua, Italy;Division of Dermatology, Department of Medicine (DIMED), University of Padova, 35128, Padua, Italy;

关键词: PFAS;    Perfluoroalkyl substances;    Compounds;    Melanoma;    Cutaneous melanoma;    Skin cancer;    Endocrine disruptor;    Vitamin D;    PFOA;    PFOS;   

DOI  :  10.1186/s12940-022-00944-x

 received in 2022-08-17, accepted in 2022-11-28,  发布年份 2022

来源: Springer

【 摘 要 】

Per- and polyfluoroalkyl substances (PFAS) are endocrine disrupting chemicals which could be associated with cancer development, such as kidney and testicular cancers, pancreatic and hepatocellular carcinoma and thyroid tumor. Available scientific literature offers no information on the role of PFAS in melanoma development/progression. Since 1965, a massive environmental contamination by PFAS has occurred in northeastern Italy. This study compared histopathology and prognosis between melanoma patients exposed (n = 194) and unexposed (n = 488) to PFAS. All patients were diagnosed and/or treated for melanoma at the Veneto Oncological Institute and the University Hospital of Padua (Italy) in 1998–2014. Patients were categorized in exposed or unexposed groups according to their home address and the geographical classification of municipalities affected by PFAS contamination as provided by Veneto Government in 2018. Presence of mitoses was found in 70.5% of exposed patients and 58.7% of unexposed patients (p = 0.005). Median follow-up was 90 months (IQR 59–136). 5-year overall survival was 83.7% in exposed patients and 88.0% in unexposed patients (p = 0.20); 5-year disease-specific survival was 88.0% in exposed patients and 90.9% in unexposed patients (p = 0.50); 5-year disease-free survival was 83.8% in exposed patients and 87.3% in unexposed patients (p = 0.20). Adjusting for imbalanced characteristics at baseline (presence of mitoses), survival was not statistically different between exposed and unexposed patients (overall survival: HR 1.10, 95% CI 0.77 to 1.58, p = 0.57; disease-specific survival: HR 0.99, 95% CI 0.62 to 1.59, p = 0.99; disease-free survival: HR 1.10, 95% CI 0.74 to 1.64, p = 0.62). Although the magnitude of PFAS exposure was not quantifiable, our findings suggested that exposure to PFAS was associated with higher level of mitosis in melanoma patients, but this did not translate into a survival difference. Further studies are required to investigate this relationship and all effects of PFAS on prognosis.

【 授权许可】

CC BY   
© The Author(s) 2022. corrected publication 2022

【 图 表 】

Fig. 2