Serum uric acid/creatinine ratio and free androgen index are synergistically associated with increased risk of polycystic ovary syndrome in obese women

BMC Endocrine Disorders

Research

Nancy Mahsoub¹  Nermeen Shams-Eldin²  Rania Bahriz³  Mervat M El-Eshmawy³  Asmaa Ibrahim⁴ 

[1] Clinical Pathology Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt;Gynecology and Obstetric Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt;Internal Medicine Department, Mansoura Specialized Medical Hospital, Faculty of Medicine, Mansoura University, P.O. Box: 35516, Mansoura, Egypt;Internal Medicine Department, Meet Salsil Central Hospital, Ministry of Health and Population, Meet Salsil, Egypt;

关键词: Polycystic ovary syndrome;    Serum uric acid/creatinine ratio;    Free androgen index;   

DOI  :  10.1186/s12902-022-01240-y

 received in 2022-04-29, accepted in 2022-12-07,  发布年份 2022

来源: Springer

【 摘 要 】

BackgroundFeatures of metabolic syndrome such as abdominal obesity, insulin resistance, hypertension and dyslipidemia are commonly encountered in polycystic ovary syndrome (PCOS). Recent evidence has suggested an association between high serum uric acid/creatinine (UA/Cr) ratio and metabolic syndrome however, no studies have investigated this association in PCOS. The current study was conducted to investigate the relationship between UA/Cr ratio and PCOS and to identify whether UA/Cr ratio and free androgen index (FAI) have an additive interaction for detection of PCOS risk in obese women.MethodsThis study enrolled 40 obese women with PCOS and 40 control women with regular menstrual cycles matched for age and body mass index (BMI). Anthropometric measurements, fasting glucose, fasting insulin, homeostasis model assessment of insulin resistance (HOMA-IR), lipids profile, luteinizing hormone (LH), follicle stimulating hormone (FSH), estradiol, dehydroepiandrosterone sulfate (DHEAS), sex hormone binding globulin (SHBG), total testosterone, free androgen index (FAI), UA/Cr ratio were assessed.ResultsSerum UA/Cr ratio was significantly higher in obese women with PCOS than in non-PCOS women. UA/Cr ratio was correlated with BMI, waist and neck circumferences, blood pressure, fasting insulin, HOMA-IR, lipids, LH/FSH, estradiol, DHEAS, total testosterone, FAI and SHBG. UA/Cr ratio and FAI were independent risk factors for PCOS in obese women however, the addictive interaction between UA/Cr ratio and FAI had a higher fold risk (OR: 4.3, 95% CI, 3.4–7.58) and a more significance (P = 0.002) for determination of PCOS.ConclusionSerum UA/Cr ratio combined with FAI can exert an additive or synergistic impact on prediction of PCOS in obese women.

【 授权许可】

CC BY   
© The Author(s) 2022

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