Pharmacodynamic properties for inhibition of cAMP- and cGMP elimination by pentoxifylline remain unaltered in vitro during hypothermia

Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine

Original Research

Timofey Kondratiev¹  Georg Sager²  Anders Lund Selli²  Natalia Smaglyukova²  Erik Sveberg Dietrichs³  Adrina Kalasho Kuzmiszyn⁴  Ole-Martin Fuskevåg⁵ 

[1] Anesthesia and Critical Care Research Group, Department of Clinical Medicine, UiT - The Arctic University of Norway, Tromsø, Norway;Department of Medical Biology, Experimental and Clinical Pharmacology, UiT – The Arctic University of Norway, Tromsø, Norway;Department of Medical Biology, Experimental and Clinical Pharmacology, UiT – The Arctic University of Norway, Tromsø, Norway;Center for Psychopharmacology, Diakonhjemmet Hospital, Oslo, Norway;Department of Medical Biology, Experimental and Clinical Pharmacology, UiT – The Arctic University of Norway, Tromsø, Norway;Research and Development Department, Norwegian Air Ambulance Foundation, Oslo, Norway;Division of Surgical Medicine and Intensive Care, University Hospital of North Norway, Tromsø, Norway;Division of Diagnostic Services, Department of Laboratory Medicine, University Hospital of North Norway, Tromsø, Norway;

关键词: Hypothermia;    PDE-inhibitors;    Cyclic AMP;    Cyclic GMP;    Blood viscosity;    Inotropy;    Afterload reduction;    Cardiovascular dysfunction;   

DOI  :  10.1186/s13049-022-01060-y

 received in 2022-09-16, accepted in 2022-11-30,  发布年份 2022

来源: Springer

【 授权许可】

CC BY   
© The Author(s) 2022

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