Altered DNA methylation in estrogen-responsive repetitive sequences of spermatozoa of infertile men with shortened anogenital distance

Clinical Epigenetics

Research

Matthias Beyens¹  Ariane Paoloni-Giacobino²  Ludwig Stenz²  Mark E. Gill³  Christian De Geyter⁴ 

[1] BISC Global, Bioinformatics and Statistics Consulting, Gaston Crommenlaan, 8, 9050, Ghent, Belgium;Department of Genetic Medicine and Development, Faculty of Medicine, University of Geneva, Rue Michel-Servet, 1, 1211, Geneva, Switzerland;Swiss Centre for Applied Human Toxicology (SCAHT), Missionsstrasse, 64, 4055, Basel, Switzerland;Reproductive Medicine and Gynecological Endocrinology (RME), University Hospital, University of Basel, Vogesenstrasse, 134, 4031, Basel, Switzerland;Swiss Centre for Applied Human Toxicology (SCAHT), Missionsstrasse, 64, 4055, Basel, Switzerland;Reproductive Medicine and Gynecological Endocrinology (RME), University Hospital, University of Basel, Vogesenstrasse, 134, 4031, Basel, Switzerland;

关键词: Infertility;    Protamine;    Apoptosis;    Methylation;    Estrogen response element;    Spermatozoa;    Anogenital distance;    Epigenome;    Histone;    Testicular dysgenesis syndrome;   

DOI  :  10.1186/s13148-022-01409-1

 received in 2022-06-16, accepted in 2022-12-14,  发布年份 2022

来源: Springer

【 授权许可】

CC BY   
© The Author(s) 2022

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