The value of QT interval in differentiating vasovagal syncope from epilepsy in children

Italian Journal of Pediatrics

Research

Shuo Wang¹  Fang Li²  Hong Cai²  Yuwen Wang²  Runmei Zou²  Cheng Wang²  Yi Xu²  Haihui Xiao³  Xin Wang⁴  Liqun Liu⁵ 

[1] Department of Neonatology, Xiangya Hospital, Central South University, 410008, Changsha, Hunan, China;Department of Pediatric Cardiovasology, Children’s Medical Center, The Second Xiangya Hospital, Central South University, No.139 Renmin Middle Road, 410011, Changsha, Hunan, China;Department of Pediatric Cardiovasology, Children’s Medical Center, The Second Xiangya Hospital, Central South University, No.139 Renmin Middle Road, 410011, Changsha, Hunan, China;Department of Pediatrics, Loudi Central Hospital, 417099, Loudi, China;Department of Pediatric Cardiovasology, Children’s Medical Center, The Second Xiangya Hospital, Central South University, No.139 Renmin Middle Road, 410011, Changsha, Hunan, China;Department of Pediatrics, The Eighth Affiliated Hospital, Sun Yat-sen University, Fu tian, 518033, Shenzhen, Guangdong, China;Department of Pediatric Neurology, Children’s Medical Center, The Second Xiangya Hospital, Central South University, 410011, Changsha, China;

关键词: Vasovagal syncope;    Epilepsy;    Electrocardiography;    QT interval;    Differential diagnosis;    Children;   

DOI  :  10.1186/s13052-022-01388-2

 received in 2022-05-12, accepted in 2022-11-25,  发布年份 2022

来源: Springer

【 摘 要 】

BackgroundBoth vasovagal syncope (VVS) and epilepsy present with transient loss of consciousness and are often difficult to identify. Hence this study aimed to explore the value of QT interval in the differentiation of VVS and epilepsy in children.MethodsOne hundred thirteen children with unexplained transient loss of consciousness were selected. 56 children with VVS (VVS group), including 37 males and 19 females, the average age is 9.88 ± 2.55 years old. 57 children with epilepsy (epilepsy group), including 36 males and 21 females, the average age is 8.96 ± 2.67 years old. At the same time, the 60 healthy individuals (control group) were examined according to age and sex. The QT interval of 12-lead electrocardiogram in a basal state of three groups was measured and statistically analyzed by SPSS 24.0 software.ResultsCompared with the control group, (1) QTcmax, QTcmin and QTcd were significantly longer in VVS group (P < 0.05), QTmax and QTmin were significantly shorter in VVS group (P < 0.05), and there were no significant differences in QTd between the two groups (P > 0.05). (2) The QTmax and QTmin were significantly shorter in epilepsy group (P < 0.05), and there were no significant differences in QTd, QTcmax, QTcmin, QTcd between the two groups (P > 0.05). Compared with the epilepsy group, The QTcmax, QTcmin, QTcd were significantly longer in VVS group (P < 0.05), and there were no significant differences in QTd, QTmax, QTmin between the two groups (P > 0.05). When QTcmax > 479.84 ms, QTcmin > 398.90 ms and QTcd > 53.56 ms, the sensitivity and specificity of diagnosing VVS were 62.5% and 77.19%, 82.14% and 50.88%, 82.14% and 38.60% respectively.ConclusionQTcmax, QTcmin and QTcd have certain value in differentiating VVS from epilepsy in children.

【 授权许可】

CC BY   
© The Author(s) 2022

【 图 表 】

Fig. 3