Prediction of polyreactive and nonspecific single-chain fragment variables through structural biochemical features and protein language-based descriptors

BMC Bioinformatics

Research

Hocheol Lim¹  Kyoung Tai No² 

[1] The Interdisciplinary Graduate Program in Integrative Biotechnology and Translational Medicine, Yonsei University, 21983, Incheon, Republic of Korea;Bioinformatics and Molecular Design Research Center (BMDRC), 21983, Incheon, Republic of Korea;The Interdisciplinary Graduate Program in Integrative Biotechnology and Translational Medicine, Yonsei University, 21983, Incheon, Republic of Korea;Bioinformatics and Molecular Design Research Center (BMDRC), 21983, Incheon, Republic of Korea;Baobab AiBIO Co., Ltd., 21983, Incheon, Republic of Korea;

关键词: Antibody design;    Nonspecificity;    Polyreactivity;    Single-chain fragment variable;    Machine Learning;    Artificial Intelligence;   

DOI  :  10.1186/s12859-022-05010-4

 received in 2022-09-13, accepted in 2022-10-26,  发布年份 2022

来源: Springer

【 授权许可】

CC BY   
© The Author(s) 2022

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