BMC Gastroenterology | |
Sex-dependent associations between MAP3K1 gene polymorphisms and soy products with the gastric cancer risk in Korea: a case-control study | |
Research | |
Jung Hyun Kwak1  Hyun Ja Kim1  Kyu Sang Song2  Bo Youl Choi3  Chang Soo Eun4  Dong Soo Han4  Yong Sung Kim5  | |
[1] Department of Food and Nutrition, Gangneung-Wonju National University, 7 Jukheon-gil, 25457, Gangneung-si, Gangwon-do, Korea;Department of Pathology, Chungnam National University College of Medicine, Daejeon, Korea;Department of Preventive Medicine, Hanyang University College of Medicine, 222 Wangsimni-ro, Seongdong-gu, 04763, Seoul, Korea;Division of Gastroenterology, Department of Internal Medicine, Hanyang University Guri Hospital, Guri-si, Korea;Functional Genomics Institute, PDXen Biosystems Co., ETRI Convergence Commercialization Center, Daejeon, Korea; | |
关键词: Case-control studies; Stomach Neoplasms; Soy products; MAP3K1; Polymorphism; Single Nucleotide; Diet; | |
DOI : 10.1186/s12876-022-02569-3 | |
received in 2022-05-30, accepted in 2022-10-10, 发布年份 2022 | |
来源: Springer | |
【 摘 要 】
Background/ObjectivesThe hormone-dependent effect of MAP3K1 gene polymorphisms may explain sex-specific differences in gastric cancer (GC) risk. Phytoestrogens have been shown to interact with this genetic factor. Here, we investigated the association between MAP3K1 gene polymorphisms and GC risk by sex and whether these associations differ depending on soy products intake.MethodsParticipants aged 20–79 years were recruited from two hospitals between December 2002 and September 2006. In all, 440 cases and 485 controls were recruited, among, 246 pairs of cases and controls, matched by sex, age (± 5 years), study admission period (± 1 years), and hospital, were included for the analysis.ResultsIn dominant model, men with the A allele of rs252902 showed significantly increased GC risk (odd ratio; OR=2.19, 95% confidence interval; CI=1.31–3.64) compared to GG homozygotes. When stratified by intake of soy products, men with the A allele of rs252902 and low intake of soy products showed significantly higher GC risk (OR=3.29, 95% CI=1.55–6.78) than that in GG homozygotes.ConclusionsMen with the risk allele of MAP3K1 had a significantly increased GC risk compared to GG homozygotes; this trend was more pronounced in those with low intake of soy products.
【 授权许可】
CC BY
© The Author(s) 2022
【 预 览 】
Files | Size | Format | View |
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RO202305061574653ZK.pdf | 855KB | download | |
Fig. 5 | 769KB | Image | download |
【 图 表 】
Fig. 5
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