Cellular senescence in cancer: clinical detection and prognostic implications

Journal of Experimental & Clinical Cancer Research

Review

Filip Lardon¹  Jasper Verswyvel¹  Tal Flieswasser¹  Christophe Deben¹  An Wouters¹  Andreas Domen²  Hans Prenen²  Marc Peeters² 

[1] Center for Oncological Research (CORE), Integrated Personalized and Precision Oncology Network (IPPON), University of Antwerp, 2610, Wilrijk (Antwerp), Belgium;Center for Oncological Research (CORE), Integrated Personalized and Precision Oncology Network (IPPON), University of Antwerp, 2610, Wilrijk (Antwerp), Belgium;Department of Oncology, Antwerp University Hospital (UZA), 2650, Edegem (Antwerp), Belgium;

关键词: Senescence;    Oncogene-induced senescence;    Therapy-induced senescence;    SASP;    Cancer;    Detection;    Prognosis;   

DOI  :  10.1186/s13046-022-02555-3

 received in 2022-09-02, accepted in 2022-11-30,  发布年份 2022

来源: Springer

【 摘 要 】

Cellular senescence is a state of stable cell-cycle arrest with secretory features in response to cellular stress. Historically, it has been considered as an endogenous evolutionary homeostatic mechanism to eliminate damaged cells, including damaged cells which are at risk of malignant transformation, thereby protecting against cancer. However, accumulation of senescent cells can cause long-term detrimental effects, mainly through the senescence-associated secretory phenotype, and paradoxically contribute to age-related diseases including cancer. Besides its role as tumor suppressor, cellular senescence is increasingly being recognized as an in vivo response in cancer patients to various anticancer therapies. Its role in cancer is ambiguous and even controversial, and senescence has recently been promoted as an emerging hallmark of cancer because of its hallmark-promoting capabilities. In addition, the prognostic implications of cellular senescence have been underappreciated due to the challenging detection and sparse in and ex vivo evidence of cellular senescence in cancer patients, which is only now catching up. In this review, we highlight the approaches and current challenges of in and ex vivo detection of cellular senescence in cancer patients, and we discuss the prognostic implications of cellular senescence based on in and ex vivo evidence in cancer patients.

【 授权许可】

CC BY   
© The Author(s) 2022

【 图 表 】

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