Clinical-epidemiological characteristics and maternal-foetal outcomes in pregnant women hospitalised with COVID-19 in Venezuela: a retrospective study

BMC Pregnancy and Childbirth

Research

Melynar Chavero¹  María V. Marcano-Rojas¹  David A. Forero-Peña²  Diana C. Freitas-De Nobrega³  Natasha A. Camejo-Ávila³  Fhabián S. Carrión-Nessi³  Augusto Moncada-Ortega⁴  Óscar D. Omaña-Ávila⁵  Daniela L. Mendoza-Millán⁵  Alfonso J. Rodriguez-Morales⁶  Mercedes P. Castro⁷  Nayren J. Trejo⁸  Isabella V. Virriel⁸ 

[1] Biomedical Research and Therapeutic Vaccines Institute, Ciudad Bolivar, Venezuela;Biomedical Research and Therapeutic Vaccines Institute, Ciudad Bolivar, Venezuela;Infectious Diseases Department, University Hospital of Caracas, Caracas, Venezuela;Biomedical Research and Therapeutic Vaccines Institute, Ciudad Bolivar, Venezuela;“Dr. Francisco Battistini Casalta” Health Sciences School, University of Oriente – Bolivar Nucleus, Ciudad Bolivar, Venezuela;Biomedical Research and Therapeutic Vaccines Institute, Ciudad Bolivar, Venezuela;“José María Vargas” School of Medicine, Central University of Venezuela, Caracas, Venezuela;Biomedical Research and Therapeutic Vaccines Institute, Ciudad Bolivar, Venezuela;“Luis Razetti” School of Medicine, Central University of Venezuela, Caracas, Venezuela;Grupo de Investigación Biomedicina, Faculty of Medicine, Fundación Universitaria Autónoma de Las Américas - Institución Universitaria Visión de Las Américas, Pereira, Risaralda, Colombia;Gilbert and Rose-Marie Chagoury School of Medicine, Lebanese American University, Beirut, Lebanon;Master of Clinical Epidemiology and Biostatistics, Universidad Científica del Sur, Lima, Peru;Obstetrics and Gynaecology Department, San Cristobal Central Hospital, San Cristobal, Venezuela;“Dr. Francisco Battistini Casalta” Health Sciences School, University of Oriente – Bolivar Nucleus, Ciudad Bolivar, Venezuela;

关键词: COVID-19;    Pregnancy;    Epidemiology;    Maternal-foetal outcome;    Venezuela;   

DOI  :  10.1186/s12884-022-05253-2

 received in 2022-09-30, accepted in 2022-11-28,  发布年份 2022

来源: Springer

【 摘 要 】

BackgroundIn low- and middle-income countries, pregnant women and newborns are more vulnerable to adverse outcomes from coronavirus disease 2019 (COVID-19). However, in Venezuela, there are no integrated data in a national surveillance system to identify the clinical-epidemiological characteristics and maternal-foetal outcomes of pregnant women hospitalised with COVID-19.MethodsA retrospective study was conducted among Venezuelan pregnant women hospitalised with COVID-19 seen at the “Ruiz y Páez” University Hospital Complex and the San Cristobal Central Hospital between June 2020 and September 2021. Information was obtained from physical and digitised clinical records using a purpose-designed proforma to collect epidemiological, clinical, paraclinical, treatment, obstetric and perinatal complications, and maternal-foetal outcomes data.ResultsA total of 80 pregnant women with confirmed severe acute respiratory syndrome coronavirus 2 infection were seen within the study period, 59 (73.8%) survived and 21 (26.2%) died. The median (interquartile range) age was 29 (23–33) years, the majority being in the third trimester of pregnancy (81.2%; n = 65). Interestingly, four (5%) pregnant women were co-infected with malaria by Plasmodium vivax and three (3.8%) with syphilis. The most frequent symptoms were fever (75%; n = 60), dry cough (68.8%; n = 55), dyspnoea (55%; n = 44), and headache (53.8%; n = 43). The most frequent maternal complications were anaemia (51.5%; n = 66) and hypertensive disorders of pregnancy (17.5%; n = 14). The most frequent perinatal complications were preterm delivery (39.2%; n = 20/51) and oligohydramnios (31.3%; n = 25). A total of 29 (36.3%) adverse foetal outcomes were documented, 21 stillbirth and eight abortions.ConclusionThis is the first study to describe the clinical-epidemiological behaviour of COVID-19 in hospitalised Venezuelan pregnant women. Anaemia, hypertensive disorders of pregnancy, oligohydramnios, and low birth weight were the most frequent maternal-foetal complications in this population of pregnant women.

【 授权许可】

CC BY   
© The Author(s) 2022

【 图 表 】

Fig. 7