Mass screening and treatment (MSaT) for identifying and treating asymptomatic cases of malaria-malaria elimination demonstration project (MEDP), Mandla, Madhya Pradesh

Malaria Journal

Research

Harpreet Kaur¹  Himanshu Jayswar²  Sneha Bhandari³  Ashok K. Mishra⁴  Rajan Poriya⁴  Aparup Das⁴  Praveen K. Bharti⁵  Akansha Singh⁵  Mrigendra P. Singh⁶  Vinay Telasey⁶  Harsh Rajvanshi⁷  Sekh Nisar⁸  Altaf A. Lal⁹ 

[1] Department of Health Research, Ministry of Health and Family Welfare, Indian Council of Medical Research, New Delhi, India;Directorate of Health Services, Government of Madhya Pradesh, Bhopal, India;Indian Council of Medical Research - National Institute of Research in Environment Health (ICMR-NIREH), Bhopal, Madhya Pradesh, India;Indian Council of Medical Research - National Institute of Research in Tribal Health (ICMR-NIRTH), Jabalpur, Madhya Pradesh, India;Indian Council of Medical Research - National Institute of Research in Tribal Health (ICMR-NIRTH), Jabalpur, Madhya Pradesh, India;Indian Council of Medical Research - National Institute of Malaria Research (ICMR-NIMR), New Delhi, India;Malaria Elimination Demonstration Project, Mandla, Madhya Pradesh, India;Malaria Elimination Demonstration Project, Mandla, Madhya Pradesh, India;Asia Pacific Leaders Malaria Alliance (APLMA), Singapore, Singapore;Malaria Elimination Demonstration Project, Mandla, Madhya Pradesh, India;Department of Health and Family Welfare, NHM Raigarh, Raigarh, Chattisgarh, India;Malaria Elimination Demonstration Project, Mandla, Madhya Pradesh, India;Foundation for Disease Elimination and Control of India, 482003, Mumbai, Maharashtra, India;

关键词: Malaria;    Mass screening and treatment;    Asymptomatic malaria;    Low-density infection;    Plasmodium falciparum;    Plasmodium vivax;   

DOI  :  10.1186/s12936-022-04423-z

 received in 2022-11-03, accepted in 2022-12-19,  发布年份 2022

来源: Springer

【 摘 要 】

BackgroundMass screening and treatment (MSaT) aims at reducing the spread of malaria in communities by identifying and treating infected persons regardless of the symptoms. This study was conducted to identify and treat asymptomatic cases using MSaT approaches in the community.MethodsThree rounds of MSaT using cluster combination approaches were carried out during September 2018 to December 2019 to identify and treat asymptomatic malaria cases in the community. All individuals who were present in the household were screened using RDT irrespective of malaria related symptoms. Simultaneously thick and thin blood smear and blood spot were collected for further analysis using microscopy and diagnostic PCR done in a subset of the samples.ResultsLogistic regression analysis revealed that asymptomatic malaria cases significantly less among the older age groups compared with < 5 years children (OR ranged between 0.52 and 0.61; p < 0.05), lowest in cluster 4 (OR = 0.01; p < 0.0001); during third round of MSaT survey (OR = 0.11; p < 0.0001) and significantly higher in moderate to high endemic areas (OR = 88.30; p < 0.0001).ConclusionOver the three rounds of MSaT, the number of asymptomatic cases were significantly less in the older age groups, and during third round. Similarly, the asymptomatic cases were significantly less in the low endemic area with API < 1 (cluster four). Therefore, the malaria elimination programme may consider the MSaT strategy to identify asymptomatic cases that would be otherwise missed by routine fever based surveillance. This MSaT strategy would help accomplish the malaria elimination goal in an expedited manner.

【 授权许可】

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© The Author(s) 2022