Mendelian randomization study of causal link from gut microbiota to colorectal cancer

BMC Cancer

Research

Xiao-Song Li¹  Bin Li¹  Gen-Hai Shen¹  Jing-Jing Ni²  Lei Zhang²  Zi-Jia Zhang³  Min Zhao⁴  Hong Zhang⁴  Qian Xu⁵  Gui-Juan Feng⁵  Xin-Tong Wei⁵ 

[1] Department of General Surgery, Suzhou Ninth Hospital Affiliated to Soochow University, 2666 Lu-dang Rd., Wujiang District, 215200, Suzhou, Jiangsu, China;Department of General Surgery, Suzhou Ninth Hospital Affiliated to Soochow University, 2666 Lu-dang Rd., Wujiang District, 215200, Suzhou, Jiangsu, China;Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou, Jiangsu, China;Center for Genetic Epidemiology and Genomics, School of Public Health, Medical College of Soochow University, 199 Ren-ai Rd., 215123, Suzhou, Jiangsu, China;Inner Mongolia Medical University, Hohhot, Inner Mongolia, China;Inner Mongolia Autonomous Region People’s Hospital, Hohhot, Inner Mongolia, China;Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou, Jiangsu, China;Center for Genetic Epidemiology and Genomics, School of Public Health, Medical College of Soochow University, 199 Ren-ai Rd., 215123, Suzhou, Jiangsu, China;Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou, Jiangsu, China;Department of Epidemiology and Health Statistics, School of Public Health, Medical College of Soochow University, Jiangsu, China;

关键词: Mendelian randomization;    Gut microbiota;    Colorectal cancer;    Causal relationship;    Blautia;   

DOI  :  10.1186/s12885-022-10483-w

 received in 2022-07-11, accepted in 2022-12-23,  发布年份 2022

来源: Springer

【 摘 要 】

Recent studies have shown the relevance of gut microbiota in the occurrence and development of colorectal cancer (CRC), but the causal relationship remains unclear in the human population. The present study aims to assess the causal relationship from the gut microbiota to CRC and to identify specific causal microbe taxa via genome-wide association study (GWAS) summary statistics based two-sample Mendelian randomization (MR) analyses. Microbiome GWAS (MGWAS) in the TwinsUK 1,126 twin pairs was used as discovery exposure sample, and MGWAS in 1,812 northern German participants was used as replication exposure sample. GWAS of CRC in 387,156 participants from the UK Biobank (UKB) was used as the outcome sample. Bacteria were grouped into taxa features at both family and genus levels. In the discovery sample, a total of 30 bacteria features including 15 families and 15 genera were analyzed. Five features, including 2 families (Verrucomicrobiaceae and Enterobacteriaceae) and 3 genera (Akkermansia, Blautia, and Ruminococcus), were nominally significant. In the replication sample, the genus Blautia (discovery beta=-0.01, P = 0.04) was successfully replicated (replication beta=-0.18, P = 0.01) with consistent effect direction. Our findings identified genus Blautia that was causally associated with CRC, thus offering novel insights into the microbiota-mediated CRC development mechanism.

【 授权许可】

CC BY   
© The Author(s) 2022

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