Long-term prognostic value of LDL-C, HDL-C, lp(a) and TG levels on cardiovascular disease incidence, by body weight status, dietary habits and lipid-lowering treatment: the ATTICA epidemiological cohort study (2002–2012)

Lipids in Health and Disease

Research

Evangelia Damigou¹  Demosthenes Panagiotakos¹  Ekavi Georgousopoulou¹  Michael Georgoulis¹  Christina Chrysohoou²  Christos Pitsavos²  Ioannis Skoumas² 

[1] Department of Nutrition and Dietetics, School of Health Sciences and Education, Harokopio University of Athens, 17676, Athens, Greece;First Department of Cardiology, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece;

关键词: Lipidemic profile;    Low-density lipoprotein cholesterol;    Lipoprotein(a);    High-density lipoprotein cholesterol;    Hyperlipidemia;    Dyslipidemia;    Triglycerides;    Cardiovascular risk;   

DOI  :  10.1186/s12944-022-01747-2

 received in 2022-10-17, accepted in 2022-12-01,  发布年份 2022

来源: Springer

【 摘 要 】

BackgroundThe link between blood lipids and cardiovascular disease (CVD) is complex. Our aim was to assess the differential effect of blood lipids on CVD risk according to age, sex, body weight, diet quality, use of lipid-lowering drugs and presence of hypercholesterolemia.MethodsIn this secondary analysis of the ATTICA prospective cohort study, serum blood lipids, i.e., total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglycerides (TG) and liproprotein(a) [Lp(a)], and sociodemographic, anthropometric, lifestyle and clinical parameters were evaluated at baseline (2001/2002) in 2020 CVD-free men and women. CVD incidence was recorded at the 10-year follow-up (2011/2012).ResultsAll blood lipids assessed were univariately related to CVD risk; however, associations remained significant only for HDL-C and TG in multivariate models adjusted for age, sex, body mass index, smoking, Mediterranean Diet Score, physical activity, presence of hypercholesterolemia, hypertension and diabetes mellitus, use of lipid-lowering drugs, and family history of CVD [RR per 1 mg/dL (95% CI): 0.983 (0.967, 1.000) and 1.002 (1.001, 1.003), respectively]. In stratified analyses, TC and LDL-C predicted CVD risk in younger subjects, normal-weight subjects, and those not on lipid-lowering drugs, while HDL-C and TG were significant predictors in older subjects, those with low adherence to the Mediterranean diet, and hypercholesterolemic subjects; a significant effect on CVD risk was also observed for TG in males, overweight participants and lipid-lowering medication users and for Lp(a) in older subjects and females (all p ≤ 0.050).ConclusionsThe impact of blood lipids on CVD risk differs according to several biological, lifestyle and clinical parameters.

【 授权许可】

CC BY   
© The Author(s) 2022