A systematic review of asymptomatic Plasmodium knowlesi infection: an emerging challenge involving an emerging infectious disease

Malaria Journal

Review

Mohammad Saffree Jeffree¹  Kamruddin Ahmed²  Rozita Hod³  Mohd Rohaizat Hassan⁴  Nurul Athirah Naserrudin⁵  Richard Culleton⁶ 

[1] Borneo Medical and Health Research Centre, Faculty of Medicine and Health Sciences, Universiti Malaysia, Sabah, Kota Kinabalu, Malaysia;Department of Community and Family Medicine, Faculty of Medicine and Health Sciences, Universiti Malaysia Sabah, Kota Kinabalu, Malaysia;Borneo Medical and Health Research Centre, Faculty of Medicine and Health Sciences, Universiti Malaysia, Sabah, Kota Kinabalu, Malaysia;Department of Pathology and Microbiology, Faculty of Medicine and Health Sciences, Universiti Malaysia Sabah, Kota Kinabalu, Malaysia;Department of Community Health, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia;Department of Community Health, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia;Borneo Medical and Health Research Centre, Faculty of Medicine and Health Sciences, Universiti Malaysia, Sabah, Kota Kinabalu, Malaysia;Department of Community Health, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia;Borneo Medical and Health Research Centre, Faculty of Medicine and Health Sciences, Universiti Malaysia, Sabah, Kota Kinabalu, Malaysia;Sabah State Health Department, Ministry of Health, Kota Kinabalu, Malaysia;Division of Molecular Parasitology, Proteo-Science Center, Ehime University, Toon, Japan;

关键词: Plasmodium knowlesi;    Zoonotic malaria;    Asymptomatic infection;    Asymptomatic characteristic;    Malaria epidemiology;   

DOI  :  10.1186/s12936-022-04339-8

 received in 2022-06-23, accepted in 2022-10-18,  发布年份 2022

来源: Springer

【 摘 要 】

BackgroundIn the last decade Plasmodium knowlesi has been detected in humans throughout South East Asia. The highest risk groups for this infection are males, adults and those performing forest-related work. Furthermore, asymptomatic cases of P. knowlesi malaria have been reported including among women and children.MethodsPubmed, Scopus and the Web of Science databases for literature describing asymptomatic P. knowlesi malaria published between 2010 and 2020 were searched. A systematic literature review was conducted to identify studies reporting the prevalence and incidence of laboratory confirmed asymptomatic P. knowlesi cases in humans, their clinical and demographic characteristics, and methods used to diagnose these cases.ResultsBy analysing over 102 papers, thirteen were eligible for this review. Asymptomatic P. knowlesi infections have been detected in 0.03%–4.0% of the population depending on region, and infections have been described in children as young as 2 years old. Various different diagnostic methods were used to detect P. knowlesi cases and there were differing definitions of asymptomatic cases in these studies. The literature indicates that regionally-differing immune-related mechanisms may play a part on the prevalence of asymptomatic P. knowlesi.ConclusionDiffering epidemiological characteristics of asymptomatic P. knowlesi malaria in different regions reinforces the need to further investigate disease transmission mechanics. Effective public health responses to changes in P. knowlesi epidemiology require proactive intervention and multisectoral collaboration.

【 授权许可】

CC BY   
© The Author(s) 2022

【 图 表 】

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