Effects of chronotype on antidepressant treatment and symptoms in patients with depression: a multicenter, parallel, controlled study

BMC Psychiatry

Research

Shanfei Cheng¹  Weiquan Huang²  Huanxin Chen²  Liang Lv³  Guilan Sun³  Mincai Qian³  Shikai Wang³  Min Feng³  Yu Fang³  Shengliang Yang³  Ping Guo³ 

[1]Department of Anesthesiology, Huzhou Third Municipal Hospital, The Affiliated Hospital of Huzhou University, 313000, Huzhou, China

[2]Department of Laboratory, Huzhou Third Municipal Hospital, The Affiliated Hospital of Huzhou University, 313000, Huzhou, China

[3]Department of Psychiatry, Huzhou Third Municipal Hospital, The Affiliated Hospital of Huzhou University, No. 2088 of Tiaoxi East Road, Wuxing District, 313000, Huzhou, Zhejiang, China

关键词: Depression;    Biorhythm;    Chronotype;    Anhedonia;    Antidepressant treatment;   

DOI  :  10.1186/s12888-023-04721-z

 received in 2023-01-12, accepted in 2023-03-27,  发布年份 2023

来源: Springer

【 摘 要 】

AimTo analyze the changes of chronotypes in patients with depression before and after treatment, and explore the effects of different chronotypes on antidepressant treatment and the dimensions of common symptoms in patients with depression.Methods180 patients with depression were selected from 10 tertiary psychiatric hospitals in Zhejiang province, according to the scores of morningness-eveningness questionnaire (MEQ), the patients were divided into three groups: early-type group, middle-type group and late-type group. The 17-item Hamilton Depression Rating Scale (HAMD-17), Hamilton Anxiety Rating Scale anxiety Scale (HAMA), Snaith Hamilton Pleasure Scale (SHAPS), multidimensional fatigue inventory-20(MFI-20) and Pittsburgh sleep quality index (PSQI) were measured at baseline and at the end of the 2nd, 4th, 8th and 12th weeks, the variance analysis of repeated measures was used to analyze the change of each index in the study. The remission rate of depression at each time point was statistically analyzed.ResultsOf the 180 patients included in the study, 26 were lost to follow-up, and 154 were finally included in the analysis. At baseline, 14.93%, 56.5% and 28.57% of the subjects were diagnosed as middle-late type, middle-late type and early-late type respectively, the total scores of Shaps and MFI-20 in the early-type group were higher than those in the late-type group and the middle-type group (p < 0.05). During the 12-week antidepressant treatment period, the time effect of PSQI, Shaps, MFI-20 and MEQ had interaction with different time groups (p < 0.05). During the treatment, the multiple symptom dimensions of depression were improved to different degrees, but the changing trend was not the same, and the recovery of the anhedonia was obviously delayed, in early-type patients, there are many symptoms such as loss of pleasure and sleep disorders. There was no significant effect on the remission rate of depression in different time type (p > 0.05) .ConclusionThe disorder of chronotypes is common in patients with depression. The time effect of different time type on different symptom dimension of depression was affected, but the effect on remission rate of depression was not significant. To strengthen the management of biological chronotype rhythm in patients with depression may be of great significance in the treatment of depression.

【 授权许可】

CC BY   
© The Author(s) 2023

【 图 表 】

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