Association between triglyceride glucose index and risk of cerebrovascular disease: systematic review and meta-analysis

Cardiovascular Diabetology

卷:21

Review

Yani Cui¹  Feifei Yan¹  Fang Fang¹  Feinan Chen¹  Jing Wang¹  Weiwei Cui¹  Shoumeng Yan² 

[1] Department of Nutrition and Food Hygiene, School of Public Health, Jilin University, 1163 Xinmin Avenue, 130021, Changchun, P. R. China;

[2] School of Nursing, Jilin University, 130021, Changchun, P. R. China;

关键词: Triglyceride glucose index;    Cerebrovascular disease;    Observational research;    meta‒analysis;    Dose‒response relationship;   

DOI  :  10.1186/s12933-022-01664-9

 received in 2022-06-30, accepted in 2022-10-12,  发布年份 2022

来源: Springer

【 摘 要 】

BackgroundThe triglyceride glucose (TyG) index, which is a new surrogate indicator of insulin resistance (IR), is thought to be associated with many diseases, such as cardiovascular disease, but its relationship with cerebrovascular disease is still controversial.MethodsThe PubMed, EMBASE, Cochrane Library, Web of Science and Medline databases were searched until March 2022 to evaluate the association between the TyG index and cerebrovascular disease risk. A random‒effects model was used to calculate the effect estimates and 95% confidence intervals (CIs).ResultsA total of 19 cohort studies and 10 case‒control/cross‒sectional studies were included in our study, which included 11,944,688 participants. Compared with a low TyG index, a higher TyG index increased the risk of cerebrovascular disease (RR/HR = 1.22, 95% CI [1.14, 1.30], P<  0.001; OR = 1.15, 95% CI [1.07, 1.23], P<  0.001). Furthermore, the results of the dose-response analysis of the cohort study demonstrated that the risk of cerebrovascular disease increased by 1.19 times per 1 mg/dl increment of the TyG index (relative risk = 1.19, 95% CI [1.13,1.25], P<  0.001).ConclusionTyG index is related to cerebrovascular disease. More data and basic research are needed to confirm the association.

【 授权许可】

CC BY   
© The Author(s) 2022

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