Comparing the expression levels of tripartite motif containing 28 in mild and severe COVID-19 infection

Virology Journal

卷:19

Research

Sana Eybpoosh¹  Abolfazl Fateh²  Enayat Anvari³  Iraj Ahmadi³  Rezvan Tavakoli⁴  Mohammadreza Aghasadeghi⁵  Pooneh Rahimi⁵  Mojtaba Hamidi-Fard⁵  Delaram Doroud⁶ 

[1] Department of Epidemiology and Biostatistics, Research Centre for Emerging and Reemerging Infectious Diseases, Pasteur Institute of Iran, Tehran, Iran;

[2] Department of Mycobacteriology and Pulmonary Research, Pasteur Institute of Iran, Tehran, Iran;Microbiology Research Center (MRC), Pasteur Institute of Iran, Tehran, Iran;

[3] Department of Physiology, School of Medicine, Ilam University of Medical Science, Ilam, Iran;

[4] Hepatitis and AIDS Department, Pasteur Institute of Iran, Tehran, Iran;

[5] Hepatitis and AIDS Department, Pasteur Institute of Iran, Tehran, Iran;Viral Vaccine Research Center, Pasteur Institute of Iran, Tehran, Iran;

[6] Quality Control Department, Production and Research Complex, Pasteur institute of Iran, Tehran, Iran;

关键词: Tripartite motif containing 28;    Coronavirus disease 2019;    Mild infection;    Severe infection;   

DOI  :  10.1186/s12985-022-01885-0

 received in 2022-03-08, accepted in 2022-09-26,  发布年份 2022

来源: Springer

【 摘 要 】

BackgroundTripartite motif-containing 28 (TRIM28) is an impressive regulator of the epigenetic control of the antiviral immune response. This study evaluated if the differential expression of TRIM28 correlates with the severity of coronavirus disease 2019 (COVID-19) infection.MethodsA total of 330 COVID-19 patients, including 188 mild and 142 severe infections, and 160 healthy controls were enrolled in this study. Quantitative real-time polymerase chain reaction (qPCR) was used to determine the expression levels of TRIM28 in the studied patients.ResultsTRIM28 mRNA levels were significantly lower in both groups of patients versus the control group and in the severe group indicated further reduction in comparison to mild infection. The multivariate logistic regression analysis showed the mean age, lower levels of low-density lipoprotein (LDL), high-density lipoprotein (HDL), cholesterol, lower 25-hydroxyvitamin D, and PCR cycle threshold (Ct) value and higher levels of erythrocyte sedimentation rate (ESR) and differential expression of TRIM28 were linked to the severity of COVID-19 infection.ConclusionThe results of this study proved that the downregulation of TRIM28 might be associated with the severity of COVID-19 infection. Further studies are required to determine the association between the COVID-19 infection severity and TRIM family proteins.

【 授权许可】

CC BY   
© The Author(s) 2022. corrected publication 2022

【 图 表 】

Fig. 5