Basement membrane-related regulators for prediction of prognoses and responses to diverse therapies in hepatocellular carcinoma

BMC Medical Genomics

卷:16

Research

Yixin Jing¹  Rong Chen¹  Qingtao Meng¹  Ruili Ding¹  Chuanbing Zhao² 

[1] Department of Anesthesiology, Renmin Hospital of Wuhan University, No.238, Jiefang Road, 430061, Wuhan, Hubei Province, China;

[2] Department of Pancreatic Surgery, Renmin Hospital of Wuhan University, No.238, Jiefang Road, 430061, Wuhan, Hubei Province, China;

关键词: Hepatocellular carcinoma;    BMR;    Basement membrane;    Drug sensitivity;    Immunotherapy;   

DOI  :  10.1186/s12920-023-01504-z

 received in 2023-01-03, accepted in 2023-03-28,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundHepatocellular carcinoma (HCC) remains a global health threat. Finding a novel biomarker for assessing the prognosis and new therapeutic targets is vital to treating this patient population. Our study aimed to explore the contribution of basement membrane-related regulators (BMR) to prognostic assessment and therapeutic response prediction in HCC.Material and methodsThe RNA sequencing and clinical information of HCC were downloaded from TCGA-LIHC, ICGC-JP, GSE14520, GSE104580, and CCLE datasets. The BMR signature was created by the Least Absolute Shrinkage and Selection Operator (LASSO) algorithm and used to separate HCC patients into low- and high-risk groups. We conducted analyses using various R 4.1.3 software packages to compare prognoses and responses to immunotherapy, transcatheter arterial chemoembolization (TACE), and chemotherapeutic drugs between the groups. Additionally, stemness indices, molecular functions, and somatic mutation analyses were further explored in these subgroups.ResultsThe BMR signature included 3 basement membrane-related genes (CTSA, P3H1, and ADAM9). We revealed that BMR signature was an independent risk contributor to poor prognosis in HCC, and high-risk group patients presented shorter overall survival. We discovered that patients in the high-risk group might be responsive to immunotherapy, while patients in the low-risk group may be susceptible to TACE therapy. Over 300 agents were screened to identify effective drugs for the two subgroups.ConclusionOverall, basement membrane-related regulators represent novel biomarkers in HCC for assessing prognosis, response to immunotherapy, the effectiveness of TACE therapy, and drug susceptibility.

【 授权许可】

CC BY   
© This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2023

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