Small nodules (≤ 6 mm in diameter) of multiple primary lung cancers: prevalence and management

Journal of Cardiothoracic Surgery

卷:17

Research Article

Yu-jing Lin¹  Xue-guo Liu²  Xiang-wen Wu³  Xiao-jin Wang³  Xiao-jian Li³  Qing-dong Cao³  Wen-hao Li³  Hong-cheng Zhong³  Hua Cheng³ 

[1] Department of Pathology, The Fifth Affiliated Hospital of Sun Yat-Sen University, Zhuhai, People’s Republic of China;

[2] Department of Radiology, The Fifth Affiliated Hospital of Sun Yat-Sen University, Zhuhai, People’s Republic of China;

[3] Department of Thoracic Surgery, The Fifth Affiliated Hospital of Sun Yat-Sen University, No. 52 Meihua Dong Road, 519000, Zhuhai, Guangdong Province, People’s Republic of China;

关键词: Multiple primary lung cancer;    Non-dominant tumor;    Comprehensive histological assessment;    Interval growth;   

DOI  :  10.1186/s13019-022-02022-2

 received in 2022-02-04, accepted in 2022-10-14,  发布年份 2022

来源: Springer

【 摘 要 】

BackgroundSynchronous multiple primary lung cancers associated with small non-dominant nodules are commonly encountered. However, the incidence, follow-up, and treatment of small non-dominant tumors have been but little studied. We explored the prevalence and management of small non-dominant tumors and factors associated with interval growth.MethodsThis observational, consecutive, retrospective single-center study enrolled patients diagnosed with synchronous multiple primary lung cancers and small non-dominant tumors (≤ 6 mm in diameter) who underwent resection of the dominant tumor. The incidence, follow-up, and management of small non-dominant tumors and predictors of nodule growth were analyzed.ResultsThere were 88 patients (12% of all lung cancer patients) with pathological diagnoses of synchronous multiple primary lung cancers. A total of 131 (18%) patients were clinically diagnosed with at least one small (≤ 6 mm in diameter) multiple primary lung cancer non-dominant tumor. 94 patients with 125 small-nodule non-dominant tumors clinically diagnosed as multiple primary lung cancers were followed-up for at least 6 months. A total of 29 (29/125, 23.2%) evidenced small pulmonary nodules (≤ 6 mm in diameter) that exhibited interval growth on follow-up computed tomography (CT). On multivariate analysis, a part-solid nodule (compared to a pGGN) (OR 1.23; 95% CI 1.08–1.40) or a solid nodule (compared to a pGGN) (OR 3.50; 95% CI 1.94–6.30) predicted small nodule interval growth.ConclusionWe found a relatively high incidence of multiple primary lung cancers with small non-dominant tumors exhibiting interval growth on follow-up CT, suggesting that resection of non-dominant tumors at the time of dominant tumor resection, especially when the nodules are part-solid or solid, is the optimal treatment.

【 授权许可】

CC BY   
© The Author(s) 2022

【 图 表 】

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