Assessment of cardiopulmonary manifestations and its correlation with semi-quantitative scoring of high-resolution computed tomography in patients with autoimmune rheumatic diseases

BMC Pulmonary Medicine

Research

Mai M. Abdalraouf¹  Samah A. Elbeltagy²  Amal A. El-Koa²  Mai M. El-Kalashy²  Enas S. Zahran³  Maha M. Salman⁴  Shrief R. Abd Elrahman⁵ 

[1]Cardiology, Faculty of Medicine, Menoufia University, Shibin Al Kawm, Egypt

[2]Chest Disease and Tuberculosis, Faculty of Medicine, Menoufia University, Shibin Al Kawm, Egypt

[3]Internal Medicine, Rheumatology and Clinical Immunology Unit, Faculty of Medicine, Menoufia University, Shibin Al Kawm, Egypt

[4]Physical Medicine, Rheumatology and Rehabilitation, Faculty of Medicine, Menoufia University, Shibin Al Kawm, Egypt

[5]Radiodiagnosis, Faculty of Medicine, Menoufia University, Shibin Al Kawm, Egypt

关键词: HRCT;    Autoimmune rheumatic diseases;    Semi-quantitative score;    Echocardiography;   

DOI  :  10.1186/s12890-023-02404-9

 received in 2022-08-24, accepted in 2023-03-30,  发布年份 2023

来源: Springer

【 摘 要 】

PurposeAutoimmune rheumatic diseases (ARD) are groups of diseases that are commonly associated with cardiac and pulmonary manifestations and may affect the morbidity and mortality of the patients. The study aimed to the assessment of cardiopulmonary manifestations and their correlation with the semi-quantitative scoring of high-resolution computed tomography (HRCT) in ARD patients.Methods and patients30 patients with ARD were included in the study (mean age 42.2 ± 9.76 years) [10 patients were scleroderma (SSc), 10 patients were rheumatoid arthritis (RA), and 10 patients were systemic lupus erythematosus (SLE)]. They all met the diagnostic criteria of the American College of Rheumatology and underwent spirometry, echocardiography, and chest HRCT. The HRCT was assessed by a semi-quantitative score for parenchymal abnormalities. Correlation between HRCT lung scores and: inflammatory markers, lung volumes in spirometry, and echocardiographic indices has been performed.ResultsThe total lung score (TLS) by HRCT was 14.8 ± 8.78 (mean ± SD), ground glass opacity score (GGO) was 7.20 ± 5.79 (mean ± SD) and fibrosis lung score (F) was 7.63 ± 6.05 (mean ± SD). TLS correlated significantly with ESR (r 0.528, p 0.003), CRP (r 0.439, p 0.015), PaO2 (r -0.395, P 0.031) FVC% (r -0.687, p 0.001), and echocardiographic Tricuspid E (r -0.370, p 0.044), Tricuspid E/è (r -0.397,p 0.03), ESPAP (r 0.459,p 0.011), TAPSE (r -0.405, p 0.027), MPI-TDI (r -0.428, p 0.018) and RV Global strain(r -0.567, p 0.001). GGO score correlated significantly with ESR (r 0.597, p 0.001), CRP (r 0.473, p 0.008), FVC% (r -0.558, p 0.001), and RV Global strain(r -0.496, p 0.005). F score correlated significantly with FVC% (r -0.397, p 0.030), Tricuspid E/è (r -0.445, p 0.014), ESPAP (r 0.402, p 0.028), and MPI-TDI (r -0.448, p 0.013).ConclusionThe total lung score and GGO score in ARD were found to be consistently significantly correlated with FVC% predicted, PaO2, inflammatory markers, and RV functions. Fibrotic score correlated with ESPAP. Therefore, in a clinical setting, most clinicians who monitor patients suffering from ARD should concern with the applicability of semiquantitative HRCT scoring in clinical practice.

【 授权许可】

CC BY   
© The Author(s) 2023

【 图 表 】

Fig. 3