Knowledge gaps and research priorities in adult veno-arterial extracorporeal membrane oxygenation: a scoping review

Intensive Care Medicine Experimental

卷:10

Reviews

Roberto Lorusso¹  Senta Jorinde Raasveld²  Alexander P. J. Vlaar²  Carolien Volleman³  Charissa E. van den Brom⁴  Fabio Silvio Taccone⁵  Lars Mikael Broman⁶  Holger Thiele⁷  Sanne ten Berg⁸  Elma Peters⁸  José P. S. Henriques⁸  Alain Combes⁹ 

[1] Department of Cardio-Thoracic Surgery, Heart and Vascular Centre, Maastricht University Medical Centre (MUMC), Cardiovascular Research Institute Maastricht (CARIM), Maastricht, The Netherlands;

[2] Department of Critical Care, Amsterdam University Medical Centers, Location Academic Medical Center, Amsterdam, The Netherlands;

[3] Department of Critical Care, Amsterdam University Medical Centers, Location Academic Medical Center, Amsterdam, The Netherlands;Laboratory of Experimental Intensive Care and Anesthesiology, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands;

[4] Department of Critical Care, Amsterdam University Medical Centers, Location Academic Medical Center, Amsterdam, The Netherlands;Laboratory of Experimental Intensive Care and Anesthesiology, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands;Department of Anesthesiology, Amsterdam UMC, VU University, Amsterdam, The Netherlands;

[5] Department of Intensive Care, Université Libre de Bruxelles, Hôpital Universitaire de Bruxelles (HUB), Brussels, Belgium;

[6] Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden;Perioperative Medicine and Intensive Care, Karolinska Institutet, Stockholm, Sweden;

[7] Heart Center Leipzig at University of Leipzig and Leipzig Heart Science GmbH, Leipzig, Germany;

[8] Heart Center, Department of Cardiology, Amsterdam Cardiovascular Sciences, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands;

[9] Institute of Cardiometabolism and Nutrition, Sorbonne Université, INSERM, UMRS1166-ICAN, Paris, France;Service de Médicine Intensive-Réanimation, Institut de Cardiologie, APHP Sorbonne Hospital Pitié-Salpêtrière, Paris, France;

关键词: Veno-arterial extracorporeal membrane oxygenation;    Extracorporeal cardiopulmonary resuscitation;    Research gaps;   

DOI  :  10.1186/s40635-022-00478-z

 received in 2022-09-28, accepted in 2022-11-14,  发布年份 2022

来源: Springer

【 摘 要 】

PurposeThis scoping review aims to identify and describe knowledge gaps and research priorities in veno-arterial extracorporeal membrane oxygenation (VA-ECMO).MethodsAn expert panel was recruited consisting of eight international experts from different backgrounds. First, a list of priority topics was made. Second, the panel developed structured questions using population, intervention, comparison and outcomes (PICO) format. All PICOs were scored and prioritized. For every selected PICO, a structured literature search was performed.ResultsAfter an initial list of 49 topics, eight were scored as high-priority. For most of these selected topics, current literature is limited to observational studies, mainly consisting of retrospective cohorts. Only for ECPR and anticoagulation, randomized controlled trials (RCTs) have been performed or are ongoing. Per topic, a summary of the literature is stated including recommendations for further research.ConclusionsThis scoping review identifies and presents an overview of knowledge gaps and research priorities in VA-ECMO. Current literature is mostly limited to observational studies, although with increasing attention for this patient population, more RCTs are finishing or ongoing. Translational research, from preclinical trials to high-quality or randomized controlled trials, is important to improve the standard practices in this critically ill patient population.Take-home messageThis scoping review identifies and presents an overview of research gaps and priorities in VA-ECMO. Translational research, from preclinical trials to high-quality or randomized controlled trials, is important to improve the standard practices in this critically ill patient population.

【 授权许可】

CC BY   
© The Author(s) 2022

【 图 表 】

Fig. 11