ColdZyme® protects airway epithelia from infection with BA.4/5

Respiratory Research

卷:23

Correspondence

Bellmann-Weiler Rosa¹  Zaderer Viktoria²  Wilflingseder Doris²  Lass-Flörl Cornelia²  Dichtl Stefanie²  Posch Wilfried² 

[1] Department of Internal Medicine II, Medical University of Innsbruck, Innsbruck, Austria;

[2] Institute of Hygiene and Medical Microbiology, Medical University of Innsbruck, Schöpfstrasse 41/R311, 6020, Innsbruck, Austria;

关键词: SARS-CoV-2;    Prophylaxis;    Variants of concern;    BA.4;    BA.5;    Transmission;   

DOI  :  10.1186/s12931-022-02223-2

 received in 2022-08-23, accepted in 2022-10-05,  发布年份 2022

来源: Springer

【 摘 要 】

Vaccines against SARS-CoV-2 protect from critical or severe pathogenesis also against new variants of concern (VOCs) such as BA.4 and BA.5, but immediate interventions to avoid viral transmission and subsequent inflammatory reactions are needed. Here we applied the ColdZyme® medical device mouth spray to fully differentiated, polarized human epithelium cultured at an air-liquid interphase (ALI). We found using VOCs BA.1 and BA.4/5 that this device effectively blocked respiratory tissue infection. While infection with these VOCs resulted in intracellular complement activation, thus enhanced inflammation, and drop of transepithelial resistance, these phenomena were prevented by a single administration of this medical device. Thus, ColdZyme® mouth spray significantly shields epithelial integrity, hinders virus infection and blocks in a secondary effect intrinsic complement activation within airway cultures also in terms of the highly contagious VOCs BA.4/5. Crucially, our in vitro data suggest that ColdZyme® mouth spray may have an impact to protect against SARS-CoV-2 transmission, also in case of the Omicron BA.1, BA.4 and BA.5 variants.

【 授权许可】

CC BY   
© The Author(s) 2022

【 图 表 】

Fig. 2

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