New uses and formulations of glucagon for hypoglycaemia

Drugs in Context

article

Pilar I Beato-Víbora¹  Francisco J Arroyo-Díez¹ 

[1] Department of Endocrinology and Nutrition, Department of Paediatrics, Badajoz University Hospital

关键词: type 1 diabetes;    glucagon;    nasal glucagon;    hypoglycaemia;    dual-hormone artificial pancreas;    exercise;    mini-dose glucagon;    injectable glucagon.;   

DOI  :  10.7573/dic.212599

学科分类：社会科学、人文和艺术（综合）

来源: C S F Medical Communications Ltd.

【 摘 要 】

Hypoglycaemia is the more frequent complication of insulintherapy and the main barrier to tight glycaemic control.Injectable glucagon and oral intake of carbohydrates arethe recommended treatments for severe and non-severehypoglycaemia episodes, respectively. Nasal glucagon iscurrently being developed as a ready-to-use device, to simplifysevere hypoglycaemia rescue. Stable forms of liquid glucagoncould open the field for different approaches for mild tomoderate hypoglycaemia treatment, such as mini-doses ofglucagon or continuous subcutaneous glucagon infusion asa part of dual-hormone closed-loop systems. Pharmaceuticalcompanies are developing stable forms of native glucagon orglucagon analogues for that purpose.

【 授权许可】

CC BY-NC-ND