Expanding horizons for clinical applications of chloroquine, hydroxychloroquine, and related structural analogues

Drugs in Context

article

Ashutosh M Shukla¹  Aparna Wagle Shukla³ 

[1] North Florida/South Georgia, Veteran Healthcare System;Department of Medicine, Division of Nephrology, College of Medicine, University of Florida;Department of Neurology, College of Medicine, University of Florida

关键词: antimalarials;    cardiovascular disease;    chloroquine;    chronic kidney disease;    hydroxychloroquine;    rheumatology;   

DOI  :  10.7573/dic.2019-9-1

学科分类：社会科学、人文和艺术（综合）

来源: C S F Medical Communications Ltd.

【 摘 要 】

Several experimental and clinical studies have transformed thetraditional antimalarial role of chloroquine (CHQ) and relatedstructural analogues to potent therapeutic agents for a hostof nonmalarial indications. The expanding clinical applicabilityfor these drugs includes rheumatological and cardiovasculardisorders (CVD), chronic kidney disease (CKD), oncology, and avariety of nonmalarial infections. These clinical advancementsare primarily related to pleiotropic pharmacological actions ofthese drugs, including immunomodulation, anti-inflammatoryproperties, and capabilities of inducing autophagy andapoptosis at a cellular level. Historically, many clinical benefitsin nonmalarial indications were first recognized throughserendipitous observations; however, with numerous ongoingsystematic clinical studies, the clinical horizons of these drugshave a promising future.

【 授权许可】

CC BY-NC-ND