ESMO Open | |
First-in-human pharmacokinetics of tamoxifen and its metabolites in the milk of a lactating mother: a case study | |
article | |
Fedro Alessandro Peccatori1  Giovanni Codacci-Pisanelli2  Gunnar Mellgren3  Barbara Buonomo1  Eleonora Baldassarre5  Ernst Asbjorn Lien3  Ersilia Bifulco6  Steinar Hustad3  Emil Zachariassen3  Harriet Johansson8  Thomas Helland3  | |
[1] Division of Gynecologic Oncology, Department of Gynecology, IEO European Institute of Oncology IRCCS;Department of Medical and Surgical Sciences and Biotechnology, Universita degli Studi La Sapienza;Department of Clinical Science, University of Bergen;Hormone Laboratory, Department of Medical Biochemistry and Pharmacology, Haukeland University Hospital;Medical Student, Università degli Studi di Milano;Department of Biological Sciences, University of Bergen;Core Facility for Metabolomics, University of Bergen;Division of Cancer Prevention and Genetics, IEO - European Institute of Oncology IRCCS | |
关键词: tamoxifen; breastfeeding; lactation; breast cancer; human milk; | |
DOI : 10.1136/esmoopen-2020-000859 | |
学科分类:社会科学、人文和艺术(综合) | |
来源: BMJ Publishing Group | |
【 摘 要 】
Background Breast cancer represents the most frequent neoplasm diagnosed in women of childbearing age. When the tumour is oestrogen receptor-positive, tamoxifen is among the recommended endocrine treatments. Lactating women are advised not to breastfeed while receiving tamoxifen. However, information about tamoxifen transfer into breast milk is lacking.Methods We measured the concentration of tamoxifen and its metabolites by liquid chromatography-tandem mass spectrometry in the milk of a nursing mother that was treated for pregnancy-associated breast cancer diagnosed a few months after delivery. She was advised not to breastfeed her child and she collected milk samples for 23 days while the baby was fed with formula.Results Tamoxifen concentrations in milk increased reaching a maximum of 214 nM. The two active metabolitesZ-4-hydroxy-tamoxifen and Z-endoxifen, could not be quantified in milk the first days after tamoxifen intake, but increased over time and reached clinically significant levels after day 18.Conclusion 7 days) and may interfere with the normal development of the infant, mothers should not breastfeed during tamoxifen treatment.
【 授权许可】
CC BY|CC BY-NC-ND
【 预 览 】
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RO202303290004752ZK.pdf | 371KB | download |