Current challenges in the implementation of precision oncology for the management of metastatic colorectal cancer

ESMO Open

article

Sun Young Kim¹  Tae Won Kim¹ 

[1] Department of Oncology, Asan Medical Center, University of Ulsan, College of Medicine

关键词: colorectal neoplasms;    biomarkers;    antineoplastic agents;   

DOI  :  10.1136/esmoopen-2019-000634

学科分类：社会科学、人文和艺术（综合）

来源: BMJ Publishing Group

【 摘 要 】

Over the last few decades, molecularly targeted agents have been used for the treatment of metastatic colorectal cancer. They have made remarkable contributions to prolonging the lives of patients. The emergence of several biomarkers and their introduction to the clinic have also aided in guiding such treatment. Recently, next-generation sequencing (NGS) has enabled clinicians to identify these biomarkers more easily and reliably. However, there is considerable uncertainty in interpreting and implementing the vast amount of information from NGS. The clinical relevance of biomarkers other than NGS are also subjects of debate. This review covers controversial issues and recent findings on such therapeutics and their molecular targets, including VEGF, EGFR, BRAF, HER2, RAS, actionable fusions, Wnt pathway and microsatellite instability for comprehensive understanding of obstacles on the road to precision oncology in metastatic colorectal cancer.

【 授权许可】

CC BY|CC BY-NC-ND