The role of the Tei index in assessing for cardiotoxicity from anthracycline chemotherapy: a systematic review

Echo Research and Practice

article

Barker, Diane¹  Duckett, Simon¹  Satchithananda, Duwarakan¹  Patwala, Ashish¹  Heatlie, Grant¹  Kwok, Chun Shing¹  Bennett, Sadie¹  Cubukcu, Arzu³  Wong, Chun Wai¹  Griffith, Timothy¹  Oxley, Cheryl¹ 

[1] Royal Stoke University Hospital;Primary Care & Health Sciences;Macclesfield District General Hospital

关键词: myocardial performance;    index;    f Tei index;    f cardiotoxicity;    f 2D echocardiography;   

DOI  :  10.1530/ERP-20-0013

学科分类：内科医学

来源: Bioscientifica Ltd.

【 摘 要 】

Background Anthracycline agents are known to be effective in treating tumors and hematological malignancies. Although these agents improve survival, their use is associated with cardiotoxic effects, which most commonly manifests as left ventricular systolic dysfunction (LVSD). As such, guidelines recommend the periodic assessment of left ventricular ejection fraction (LVEF). However, as diastolic dysfunction likely proceeds systolic impairment in this setting, the role of Tei index may offer additional benefit in detecting subclinical LVSD. Methods We conducted a systematic review to investigate the evidence for the use of Tei index in assessing subclinical cardiotoxicity in patients receiving anticancer agents. A search of Medline and EMBASE was performed and relevant studies were reviewed and narratively synthesized. Results A total of 13 studies were included with a total of 800 patients (mean age range 46-62 years, percentage of male participants ranged from 0-86.9%). An increase in Tei index was observed in 11 studies, which suggested a decline in cardiac function following chemotherapy. Out of these, six studies indicated that the Tei index is a useful parameter in predicting cardiotoxic LVSD. Furthermore, five studies indicated Tei index to be superior to LVEF in detecting subclinical cardiotoxicity. Conclusions Though there are some studies that suggest that Tei index may be a useful indicator in assessing subclinical anthracycline-related cardiotoxicity, the findings are inconsistent and so more studies are needed before the evaluation of Tei index is performed routinely in patients receiving chemotherapy. Conclusions Though there are some studies that suggest that Tei index may be a useful indicator in assessing subclinical anthracycline-related cardiotoxicity, the findings are inconsistent and so more studies are needed before the evaluation of Tei index is performed routinely in patients receiving chemotherapy.

【 授权许可】

CC BY|CC0