Recovery from alopecia areata in a patient with autoimmune polyglandular syndrome type 3

Endocrinology, Diabetes & Metabolism Case Reports

article

Shinya Makino¹  Takeshi Uchihashi¹  Yasuo Kataoka¹  Masayoshi Fujiwara¹ 

[1] Department of Internal Medicine, Osaka Gyomeikan Hospital

关键词: Adult;    Male;    Asian - Japanese;    Japan;    Pancreas;    Skin;    Diabetes;    Insulin;    Autoimmune polyglandular syndrome;    Diabetes mellitus type 1;    Hashimoto's disease;    Thyroiditis;    Alopecia;    Polyuria;    Polydipsia;    Dehydration;    Anorexia;    Alopecia;    Glucose (blood);    Glucose (blood;    fasting);    Haemoglobin A1c;    C-peptide (blood);    C-peptide (24-hour urine);    Thyroid antibodies;    HLA genotyping;    Insulin;    Unique/unexpected symptoms or presentations of a disease;    February;    2015;   

DOI  :  10.1530/EDM-14-0084

学科分类：血液学

来源: Bioscientifica Ltd.

【 摘 要 】

Recovery from alopecia is rare in autoimmune polyglandular syndrome (APS). A 41-year-old male was admitted to ourhospital with hyperglycemia. He developed alopecia areata (AA) 5 months before admission and developed thirst, polyuria,and anorexia in 2 weeks. His plasma glucose level upon admission was 912 mg/dl (50.63 mmol/l) and HbA1c was 13.7%.Although urinary and plasma C-peptide levels showed that insulin secretion was not depleted, anti-insulinoma-associatedantigen 2 antibody was present. In addition, measurement of thyroid autoantibodies revealed the presence of Hashimoto’sthyroiditis. These findings suggested a diagnosis of APS type 3. The patient has showed signs of improvement with thecontinuation of insulin therapy. During the successful control of diabetes, he had total hair regrowth within 2–3 months.Human leukocyte antigen typing showed that DRB1*1501-DQB1*0602 and DQB1*0301 were present. Similar cases should beaccumulated to clarify the association of APS type 3 with recovery from AA.

【 授权许可】

CC BY-NC-ND