Cell cycle related long non-coding RNAs as the critical regulators of breast cancer progression and metastasis

Biological Research

article

Zangouei, Amir Sadra¹  Zangoue, Malihe³  Taghehchian, Negin⁵  Zangooie, Alireza³  Rahimi, Hamid Reza²  Saburi, Ehsan²  Alavi, Mahya Sadat²  Moghbeli, Meysam² 

[1] Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences;Department of Medical Genetics and Molecular Medicine, School of Medicine, Mashhad University of Medical Sciences;Cellular and Molecular Research Center, Birjand University of Medical Sciences;Department of Anesthesiology, Faculty of Medicine, Birjand University of Medical Sciences;Medical Genetics Research Center, Mashhad University of Medical Sciences;Student Research Committee, Birjand University of Medical Sciences

关键词: Breast cancer;    LncRNAs;    Cell cycle;    Liquid biopsy;    Diagnosis;   

DOI  :  10.1186/s40659-022-00411-4

学科分类：社会科学、人文和艺术（综合）

来源: BioMed Central

【 摘 要 】

Cell cycle is one of the main cellular mechanisms involved in tumor progression. Almost all of the active molecular pathways in tumor cells directly or indirectly target the cell cycle progression. Therefore, it is necessary to assess the molecular mechanisms involved in cell cycle regulation in tumor cells. Since, early diagnosis has pivotal role in better cancer management and treatment, it is required to introduce the non-invasive diagnostic markers. Long non-coding RNAs (LncRNAs) have higher stability in body fluids in comparison with mRNAs. Therefore, they can be used as efficient non-invasive markers for the early detection of breast cancer (BCa). In the present review we have summarized all of the reported lncRNAs involved in cell cycle regulation in BCa. It has been reported that lncRNAs mainly affect the cell cycle in G1/S transition through the CCND1/CDK4-6 complex. Present review paves the way of introducing the cell cycle related lncRNAs as efficient markers for the early detection of BCa.

【 授权许可】

CC BY|CC0