Enterovirus infection and its relationship with neurodegenerative diseases

Memorias do Instituto Oswaldo Cruz

article

Vieira, Tuane Cristine Ramos Gonçalves¹  Sousa Junior, Ivanildo Pedro² 

[1] Universidade Federal do Rio de Janeiro;Fundação Oswaldo Cruz-Fiocruz

关键词: enterovirus;    neurodegenerative diseases;    amyotrophic lateral sclerosis;    Alzheimer’s disease;    Parkinson’s disease;   

DOI  :  10.1590/0074-02760220252

学科分类：地质学

来源: Bioline International

【 摘 要 】

Neurodegenerative diseases (NDs) are increasingly common, especially in populations with higher life expectancies. They are associated mainly with protein metabolism and structure changes, leading to neuronal cell death. Viral infections affect these cellular processes and may be involved in the etiology of several neurological illnesses, particularly NDs. Enteroviruses (EVs) frequently infect the central nervous system (CNS), causing neurological disease. Inflammation, disruption of the host autophagy machinery, and deregulation and accumulation/misfolding of proteins are the main alterations observed after infection by an EV. In this perspective, we discuss the most recent findings on the subject, examining the possible role of EVs in the development of NDs, and shedding light on the putative role played by these viruses in developing NDs.

【 授权许可】

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