Alteration of nanomechanical properties of pancreatic cancer cells through anticancer drug treatment revealed by atomic force microscopy

Beilstein Journal of Nanotechnology

article

Xiaoteng Liang¹  Shuai Liu¹  Xiuchao Wang³  Dan Xia¹  Qiang Li² 

[1] School of Materials Science and Engineering, Hebei University of Technology and Tianjin Key Laboratory of Materials Laminating Fabrication and Interface Control Technology;Key Laboratory of Colloid and Interface Chemistry of Ministry of Education, And School of Chemistry and Chemical Engineering, Shandong University;Tianjin Medical University Cancer Institute & Hospital

关键词: anticancer drug;    atomic force microscopy;    nanomechanical properties;    pancreatic cancer cells;   

DOI  :  10.3762/bjnano.12.101

学科分类：环境监测和分析

来源: Beilstein - Institut zur Foerderung der Chemischen Wissenschaften

【 摘 要 】

The mechanical properties of cells are key to the regulation of cell activity, and hence to the health level of organisms. Here, themorphology and mechanical properties of normal pancreatic cells (HDPE6-C7) and pancreatic cancer cells (AsPC-1, MIA PaCa-2,BxPC-3) were studied by atomic force microscopy. In addition, the mechanical properties of MIA PaCa-2 after treatment with different concentrations of doxorubicin hydrochloride (DOX) were also investigated. The results show the Young's modulus of normalcells is greater than that of three kinds of cancer cells. The Young's modulus of more aggressive cancer cell AsPC-1 is smaller thanthat of less aggressive cancer cell BxPC-3. In addition, the Young's modulus of MIA PaCa-2 rises with the increasing of DOX concentration. This study may provide a new strategy of detecting cancer, and evaluate the possible interaction of drugs on cells.

【 授权许可】

CC BY