Indomethacin-intolerant hemicrania continua:treatment with botulinum toxin

Neurology Asia

article

Aaron de Souza¹  Lauren Giles¹ 

[1] Department of Medicine, Launceston General Hospital

关键词: Hemicrania continua;    indomethacin;    botulinum toxin;   

DOI  :  10.54029/2022wyx

学科分类：精神健康和精神病学

来源: Association of South East Asian Nations

【 摘 要 】

Hemicrania continua (HC) is responsive to indomethacin, which is useful both for acute treatmentand for chronic suppressive therapy. However, this medication is poorly tolerated in many patients.The treatment of indomethacin-intolerant HC is poorly defined. We present a patient with HC whodeveloped acute kidney injury on indomethacin and proved refractory to multiple other treatmentmodalities. She had an excellent response to botulinum toxin, with a duration of benefit similar to thatreported previously in HC and in chronic migraine. Botulinum toxin may be a therapeutic option inpatient with HC who do not tolerate indomethacin. The possible mechanisms of action of botulinumtoxin in HC are discussed.

【 授权许可】

CC BY