Reduced Contrast Sensitivity is Associated With ElevatedEquivalent Intrinsic Noise in Type 2 Diabetics Who HaveMild or No Retinopathy

Investigative Ophthalmology & Visual Science

article

J. Jason McAnany¹  Jason C. Park¹ 

[1] Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago;Department of Bioengineering, University of Illinois at Chicago

关键词: diabetic retinopathy;    contrast sensitivity;    psychophysics;    noise;    efficiency;   

DOI  :  10.1167/iovs.18-24151

学科分类：社会科学、人文和艺术（综合）

来源: Association for Research in Vision and Ophthalmology

【 摘 要 】

PURPOSE. To evaluate explanations for contrast sensitivity (CS) losses in subjects who havemild nonproliferative diabetic retinopathy (NPDR) or no diabetic retinopathy (NDR) bymeasuring and modeling CS in luminance noise.METHODS. Ten diabetic subjects with NDR, 10 with mild NPDR, and 10 age-equivalentnondiabetic controls participated. Contrast threshold energy (Et) was measured for letterspresented in the absence of noise (Et0) and in four levels of luminance noise. Data were fitwith the linear amplifier model to estimate inferred noise level within the visual pathway(Neq) and sampling efficiency (ability to use stimulus information optimally). Et0, Neq, andefficiency were compared to clinical characteristics.RESULTS. Neq was correlated with Et0 for the diabetic subjects (r ¼ 0.93, P < 0.001) and rangedfrom normal to 12-times the upper limit of normal. ANOVA indicated significant differencesamong the subject groups for Et0 and Neq (both F > 11.92, P < 0.001). Et0 and Neq wereelevated for the mild NPDR group compared to the control and NDR groups (all t > 3.89, P0.001); the NDR and control groups did not differ significantly (all t < 0.61, P > 0.55). Therewere no significant efficiency differences among the groups (F ¼ 1.29, P ¼ 0.29). Neq wascorrelated significantly with disease duration, microperimetric sensitivity, and Pelli-RobsonCS.CONCLUSIONS. Elevated contrast threshold may be associated with increased intrinsic noise inearly-stage diabetic subjects. Results suggest that noise-based CS measurements can provideimportant information about early neural dysfunction in these individuals.

【 授权许可】

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