Factors Influencing Central Lamina Cribrosa Depth: AMulticenter Study

Investigative Ophthalmology & Visual Science

article

Haomin Luo¹  Hongli Yang²  Stuart K. Gardiner³  Christy Hardin²  Glen P. Sharpe⁴  Joseph Caprioli⁵  Shaban Demirel³  Christopher A. Girkin⁶  Jeffrey M. Liebmann⁷  Christian Y. Mardin⁸  Harry A. Quigley⁹  Alexander F. Scheuerle^1,10  Brad Fortune³  Balwantray C. Chauhan⁴  Claude F. Burgoyne² 

[1] Department of Ophthalmology, Second Xiangya Hospital, Central South University, Changsha, Hunan Province;Devers Eye Institute, Optic Nerve Head Research Laboratory, Legacy Research Institute;Devers Eye Institute, Discoveries in Sight Research Laboratories, Legacy Research Institute;Ophthalmology and Visual Sciences, Dalhousie University;Jules Stein Eye Institute, David Geffen School of Medicine at University of California-Los Angeles;Department of Ophthalmology, School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama;Einhorn Clinical Research Center, Moise and Chella Safra Advanced Ocular Imaging Laboratory, New York Eye and Ear Infirmary of Mount Sinai Health System;Department of Ophthalmology, University of Erlangen;Wilmer Eye Institute, Johns Hopkins University;Department of Ophthalmology, University of Heidelberg

关键词: Bruch’s membrane;    optic nerve head;    optical coherence tomography;    glaucoma;    laminar depth;   

DOI  :  10.1167/iovs.17-23456

学科分类：社会科学、人文和艺术（综合）

来源: Association for Research in Vision and Ophthalmology

【 摘 要 】

PURPOSE. To quantify the influence of ocular and demographic factors on central laminardepth (LD) in healthy participants.METHODS. A total of 362 normal subjects underwent optical coherence tomography (OCT)enhanced depth imaging of the optic nerve head (ONH) with a 24 radial B-scan patternaligned to the fovea–to–Bruch’s membrane opening (BMO) axis. BMO, anterior lamina,anterior scleral canal opening (ASCO), Bruch’s membrane (BM), and the peripapillary scleralsurface were manually segmented. The extent of laminar segmentation was quantified within72 ASCO subsectors. Central LD was quantified relative to four reference planes: BMO, ASCO,BM, and scleral. The effects of age, sex, ethnicity, IOP, BMO area, ASCO area, and axial lengthon LD were assessed.RESULTS. Laminar visibility was most consistent within the central ASCO (median 89%, range,69%–95%). LDBMO and LDBM were significantly shallower in eyes with greater age, BMO area,and axial length and in females. LDASCO was shallower in eyes with greater ASCO area andaxial length and in European and Hispanic descent compared to African descent eyes. LDSclerabehaved similarly, but was not associated with axial length. BMO and ASCO area were notdifferent between African descent and European descent eyes.CONCLUSIONS. Central LD was deeper in African descent eyes and influenced least by age, axiallength, and sex, but more by ASCO area, when measured relative to the ASCO and sclera.However, the magnitude of these effects for all four reference planes was small, and theirclinical importance in the detection of glaucoma and its progression remains to bedetermined.

【 授权许可】

CC BY|CC BY-NC-ND