Maternal periodontitis and low birth weight: systematic review and meta-analysis

Ciencia e Saude Coletiva

article

Porto, Edla Carvalho Lima¹  Gomes Filho, Isaac Suzart¹  Batista, Josicélia Estrela Tuy¹  Lyrio, Amanda Oliveira²  Souza, Elivan Silva²  Figueiredo, Ana Claudia Morais Godoy²  Pereira, Mauricio Gomes²  Cruz, Simone Seixas da³ 

[1] Universidade Estadual de Feira de Santana;Universidade de Brasília;Universidade Federal do Recôncavo da Bahia

关键词: Periodontitis;    Low birth weight;    Systematic Review;    Meta-analysis;   

DOI  :  10.1590/1413-812320212611.3.32362019

学科分类：社会科学、人文和艺术（综合）

来源: Associacao Brasileira de Pos - Graduacao em Saude Coletiva

【 摘 要 】

Recent evidence points to the influence of periodontal inflammatory processes on the occurrence of low birth weight. Although many studies employed robust investigation methods, there is still no general agreement on the relationship between maternal periodontitis and low birth weight. The search for studies was conducted until April 2019. The studies included cohort and case-control studies that estimated the association between periodontitis and low birth weight, with no restriction on language or date of publication. Analysis of the heterogeneity of studies, subgroup analyses and meta-analyses with a random effects model were performed. Summary association measurements were estimated using the crude and adjusted Odds Ratio, with respective 95% confidence intervals. Visual inspection of graphs was used to assess publication bias. A total of 21 articles were identified, all of which were selected for the meta-analysis. The final model indicates that periodontitis in pregnant women was associated with low birth weight (ORgross=2.13; CI95%=1.60-2.83; I2=80.0% and ORadjusted=2.64; CI95%=2.04-3.42; I2=17.4%). Pregnant women with periodontitis may be more than twice as likely to have low birth weight babies.

【 授权许可】

CC BY